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SMILES: Oc1cc(ccc1Cl)-c1[nH]c(nc1-c1ccncn1)-c1ccccc1

InChI Key: InChIKey=NPGMXUVYVDMIQF-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50176326   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase B-raf


(Homo sapiens (Human))		BDBM50176326
PNG
(2-chloro-5-(2-phenyl-5-(pyrimidin-4-yl)-1H-imidazo...)
Show SMILES Oc1cc(ccc1Cl)-c1[nH]c(nc1-c1ccncn1)-c1ccccc1
Show InChI InChI=1S/C19H13ClN4O/c20-14-7-6-13(10-16(14)25)17-18(15-8-9-21-11-22-15)24-19(23-17)12-4-2-1-3-5-12/h1-11,25H,(H,23,24)
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Article
PubMed
n/an/an/a 14n/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity at bRaf kinase in fluorescent ligand displacement assay

Bioorg Med Chem Lett 16: 378-81 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.072
BindingDB Entry DOI: 10.7270/Q2Z038Z9
More data for this
Ligand-Target Pair