BDBM50260425 CHEMBL4099313
SMILES: CC(C)C[C@@H]1C[C@H](C)[C@]2(N1C(=O)c1cn(C)cn1)C(=O)Nc1ccc(F)cc21
InChI Key: InChIKey=WAFNVKVWBPXGHK-QDUSTFBWSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human)) | BDBM50260425 (CHEMBL4099313) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin... | Bioorg Med Chem 25: 4753-4767 (2017) Article DOI: 10.1016/j.bmc.2017.07.017 BindingDB Entry DOI: 10.7270/Q27M0BDH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic initiation factor 4A-III (Homo sapiens (Human)) | BDBM50260425 (CHEMBL4099313) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c... | Bioorg Med Chem 25: 4753-4767 (2017) Article DOI: 10.1016/j.bmc.2017.07.017 BindingDB Entry DOI: 10.7270/Q27M0BDH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic initiation factor 4A-I (Homo sapiens (Human)) | BDBM50260425 (CHEMBL4099313) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of elF4G-induced full length recombinant human N-terminal His6-SUMO-tagged eIF4A1 RNA dependent ATPase activity expressed in Escherichia c... | Bioorg Med Chem 25: 4753-4767 (2017) Article DOI: 10.1016/j.bmc.2017.07.017 BindingDB Entry DOI: 10.7270/Q27M0BDH | |||||||||||
More data for this Ligand-Target Pair |