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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Eukaryotic initiation factor 4A-III' and Ligand = 'BDBM50260425'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Eukaryotic initiation factor 4A-III


(Homo sapiens (Human))		BDBM50260425
PNG
(CHEMBL4099313)
Show SMILES CC(C)C[C@@H]1C[C@H](C)[C@]2(N1C(=O)c1cn(C)cn1)C(=O)Nc1ccc(F)cc21 |r|
Show InChI InChI=1S/C21H25FN4O2/c1-12(2)7-15-8-13(3)21(26(15)19(27)18-10-25(4)11-23-18)16-9-14(22)5-6-17(16)24-20(21)28/h5-6,9-13,15H,7-8H2,1-4H3,(H,24,28)/t13-,15+,21+/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
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PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...

Bioorg Med Chem 25: 4753-4767 (2017)


Article DOI: 10.1016/j.bmc.2017.07.017
BindingDB Entry DOI: 10.7270/Q27M0BDH
More data for this
Ligand-Target Pair