BDBM50261859 CHEMBL4090269

SMILES: COCC1CC1c1c(Cl)c2c(Cl)cc(nc2n1C1CCCNC1)C(N)=O

InChI Key: InChIKey=VNPQQGXWMYSECL-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50261859   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50261859 (CHEMBL4090269) Show SMILES COCC1CC1c1c(Cl)c2c(Cl)cc(nc2n1C1CCCNC1)C(N)=O Show InChI InChI=1S/C18H22Cl2N4O2/c1-26-8-9-5-11(9)16-15(20)14-12(19)6-13(17(21)25)23-18(14)24(16)10-3-2-4-22-7-10/h6,9-11,22H,2-5,7-8H2,1H3,(H2,21,25)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com. Curated by ChEMBL					Assay Description Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay				Bioorg Med Chem Lett 27: 4735-4740 (2017) Article DOI: 10.1016/j.bmcl.2017.08.068 BindingDB Entry DOI: 10.7270/Q2NG4T34
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM50261859 (CHEMBL4090269) Show SMILES COCC1CC1c1c(Cl)c2c(Cl)cc(nc2n1C1CCCNC1)C(N)=O Show InChI InChI=1S/C18H22Cl2N4O2/c1-26-8-9-5-11(9)16-15(20)14-12(19)6-13(17(21)25)23-18(14)24(16)10-3-2-4-22-7-10/h6,9-11,22H,2-5,7-8H2,1H3,(H2,21,25)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	298	n/a	n/a	n/a	n/a	n/a	n/a
IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com. Curated by ChEMBL					Assay Description Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay				Bioorg Med Chem Lett 27: 4735-4740 (2017) Article DOI: 10.1016/j.bmcl.2017.08.068 BindingDB Entry DOI: 10.7270/Q2NG4T34
					More data for this Ligand-Target Pair