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Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase pim-1' and Ligand = 'BDBM50261859'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261859
PNG
(CHEMBL4090269)
Show SMILES COCC1CC1c1c(Cl)c2c(Cl)cc(nc2n1C1CCCNC1)C(N)=O
Show InChI InChI=1S/C18H22Cl2N4O2/c1-26-8-9-5-11(9)16-15(20)14-12(19)6-13(17(21)25)23-18(14)24(16)10-3-2-4-22-7-10/h6,9-11,22H,2-5,7-8H2,1H3,(H2,21,25)
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MMDB

KEGG

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PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 42n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair