BDBM50308554 3-(4-(3-hydroxypropyl)-1,4-diazepan-1-yl)-1-(2-propoxyethyl)-7-(6-methoxypyridin-3-yl)pyrido[3,4-b]pyrazin-2(1H)-one::CHEMBL590787

SMILES: CCCOCCn1c2cc(ncc2nc(N2CCCN(CCCO)CC2)c1=O)-c1ccc(OC)nc1

InChI Key: InChIKey=PEWZFEYDMCHRJT-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50308554   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50308554 (3-(4-(3-hydroxypropyl)-1,4-diazepan-1-yl)-1-(2-pro...) Show SMILES CCCOCCn1c2cc(ncc2nc(N2CCCN(CCCO)CC2)c1=O)-c1ccc(OC)nc1 Show InChI InChI=1S/C26H36N6O4/c1-3-15-36-16-13-32-23-17-21(20-6-7-24(35-2)28-18-20)27-19-22(23)29-25(26(32)34)31-10-4-8-30(11-12-31)9-5-14-33/h6-7,17-19,33H,3-5,8-16H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assay				J Med Chem 53: 2656-60 (2010) Article DOI: 10.1021/jm901781q BindingDB Entry DOI: 10.7270/Q2VM4CCK
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