BDBM50358323 CHEMBL1922582

SMILES: CCCn1[nH]c(=O)c2cc(NC(=O)c3nc(oc3C(F)(F)F)-c3ccccc3)ccc12

InChI Key: InChIKey=OUMKAVGLHVITRR-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50358323   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Diacylglycerol O-acyltransferase 1 (DGAT1) (Homo sapiens (Human))	BDBM50358323 (CHEMBL1922582) Show SMILES CCCn1[nH]c(=O)c2cc(NC(=O)c3nc(oc3C(F)(F)F)-c3ccccc3)ccc12 Show InChI InChI=1S/C21H17F3N4O3/c1-2-10-28-15-9-8-13(11-14(15)18(29)27-28)25-19(30)16-17(21(22,23)24)31-20(26-16)12-6-4-3-5-7-12/h3-9,11H,2,10H2,1H3,(H,25,30)(H,27,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human DGAT1 expressed in CHOK1 cells using 14C palmitic acid as substrate after 1 hr by TLC analysis				Bioorg Med Chem Lett 21: 7205-9 (2011) Article DOI: 10.1016/j.bmcl.2011.09.039 BindingDB Entry DOI: 10.7270/Q2MP53P6
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1) (Homo sapiens (Human))	BDBM50358323 (CHEMBL1922582) Show SMILES CCCn1[nH]c(=O)c2cc(NC(=O)c3nc(oc3C(F)(F)F)-c3ccccc3)ccc12 Show InChI InChI=1S/C21H17F3N4O3/c1-2-10-28-15-9-8-13(11-14(15)18(29)27-28)25-19(30)16-17(21(22,23)24)31-20(26-16)12-6-4-3-5-7-12/h3-9,11H,2,10H2,1H3,(H,25,30)(H,27,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human DGAT1 using palmitoyl-1-14C coenzyme A and DAG as substrate after 1 hr by phospholipid flash plate assay				Bioorg Med Chem Lett 21: 7205-9 (2011) Article DOI: 10.1016/j.bmcl.2011.09.039 BindingDB Entry DOI: 10.7270/Q2MP53P6
					More data for this Ligand-Target Pair