BDBM50405061 CHEMBL6836

SMILES: COC(=O)c1ccc(cc1)N1C(N)=NC(N)=NC1(C)C

InChI Key: InChIKey=DTIUMMFQQKUZBT-UHFFFAOYSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50405061   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dihydrofolate reductase (Gallus gallus (Chicken))	BDBM50405061 (CHEMBL6836) Show SMILES COC(=O)c1ccc(cc1)N1C(N)=NC(N)=NC1(C)C |c:13,16| Show InChI InChI=1S/C13H17N5O2/c1-13(2)17-11(14)16-12(15)18(13)9-6-4-8(5-7-9)10(19)20-3/h4-7H,1-3H3,(H4,14,15,16,17)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.78E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)				J Med Chem 27: 129-43 (1984) BindingDB Entry DOI: 10.7270/Q2TT4S5M
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50405061 (CHEMBL6836) Show SMILES COC(=O)c1ccc(cc1)N1C(N)=NC(N)=NC1(C)C |c:13,16| Show InChI InChI=1S/C13H17N5O2/c1-13(2)17-11(14)16-12(15)18(13)9-6-4-8(5-7-9)10(19)20-3/h4-7H,1-3H3,(H4,14,15,16,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.41E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory activity against human lymphoblastoid cell (WIL2) dihydrofolate reductase (DHFR)				J Med Chem 27: 144-9 (1984) BindingDB Entry DOI: 10.7270/Q28K7C96
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Lactobacillus casei)	BDBM50405061 (CHEMBL6836) Show SMILES COC(=O)c1ccc(cc1)N1C(N)=NC(N)=NC1(C)C |c:13,16| Show InChI InChI=1S/C13H17N5O2/c1-13(2)17-11(14)16-12(15)18(13)9-6-4-8(5-7-9)10(19)20-3/h4-7H,1-3H3,(H4,14,15,16,17)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	4.07E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR)				J Med Chem 27: 129-43 (1984) BindingDB Entry DOI: 10.7270/Q2TT4S5M
					More data for this Ligand-Target Pair