Found 11 hits for monomerid = 50405959 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Dihydrofolate reductase
(Salmonella enterica subsp. enterica serovar Typhi) | BDBM50405959
(CHEMBL31912)Show InChI InChI=1S/C17H24N4O/c1-2-3-4-5-10-22-15-8-6-13(7-9-15)11-14-12-20-17(19)21-16(14)18/h6-9,12H,2-5,10-11H2,1H3,(H4,18,19,20,21) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 851 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pomona College
Curated by ChEMBL
| Assay Description Inhibitory activity against Escherichia coli dihydrofolate reductase |
J Med Chem 34: 46-54 (1991)
BindingDB Entry DOI: 10.7270/Q2X92CH4 |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Escherichia coli) | BDBM50405959
(CHEMBL31912)Show InChI InChI=1S/C17H24N4O/c1-2-3-4-5-10-22-15-8-6-13(7-9-15)11-14-12-20-17(19)21-16(14)18/h6-9,12H,2-5,10-11H2,1H3,(H4,18,19,20,21) | MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 851 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity against dihydrofolate reductase (DHFR) from Escherichia coli (expressed as log 1/Kiapp) |
J Med Chem 25: 777-84 (1982)
BindingDB Entry DOI: 10.7270/Q2WH2S6T |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Escherichia coli) | BDBM50405959
(CHEMBL31912)Show InChI InChI=1S/C17H24N4O/c1-2-3-4-5-10-22-15-8-6-13(7-9-15)11-14-12-20-17(19)21-16(14)18/h6-9,12H,2-5,10-11H2,1H3,(H4,18,19,20,21) | MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 851 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Beijing Medical University
Curated by ChEMBL
| Assay Description Apparent inhibitory (log 1/Ki) activity against Escherichia coli dihydrofolate reductase |
J Med Chem 31: 366-70 (1988)
BindingDB Entry DOI: 10.7270/Q2BV7JTC |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Escherichia coli) | BDBM50405959
(CHEMBL31912)Show InChI InChI=1S/C17H24N4O/c1-2-3-4-5-10-22-15-8-6-13(7-9-15)11-14-12-20-17(19)21-16(14)18/h6-9,12H,2-5,10-11H2,1H3,(H4,18,19,20,21) | MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 851 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uniroyal Chemical Co., Inc.
Curated by ChEMBL
| Assay Description Inhibition constant against binding of Escherichia coli dihydrofolate reductase |
J Med Chem 31: 1396-406 (1988)
BindingDB Entry DOI: 10.7270/Q2P55QQJ |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Lactobacillus casei) | BDBM50405959
(CHEMBL31912)Show InChI InChI=1S/C17H24N4O/c1-2-3-4-5-10-22-15-8-6-13(7-9-15)11-14-12-20-17(19)21-16(14)18/h6-9,12H,2-5,10-11H2,1H3,(H4,18,19,20,21) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 1.86E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pomona College
Curated by ChEMBL
| Assay Description Inhibitory activity against Lactobacillus casei dihydrofolate reductase |
J Med Chem 32: 1895-905 (1989)
BindingDB Entry DOI: 10.7270/Q2QR4ZB9 |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Lactobacillus casei) | BDBM50405959
(CHEMBL31912)Show InChI InChI=1S/C17H24N4O/c1-2-3-4-5-10-22-15-8-6-13(7-9-15)11-14-12-20-17(19)21-16(14)18/h6-9,12H,2-5,10-11H2,1H3,(H4,18,19,20,21) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 1.86E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Rap1A-mediated geranylgeranylation expressed in mouse NIH3T3 cells |
J Med Chem 25: 777-84 (1982)
BindingDB Entry DOI: 10.7270/Q2WH2S6T |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Bos taurus (Cattle)) | BDBM50405959
(CHEMBL31912)Show InChI InChI=1S/C17H24N4O/c1-2-3-4-5-10-22-15-8-6-13(7-9-15)11-14-12-20-17(19)21-16(14)18/h6-9,12H,2-5,10-11H2,1H3,(H4,18,19,20,21) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 2.82E+3 | n/a | n/a | n/a | n/a | n/a | n/a | 7.2 | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity against bovine liver Dihydrofolate reductase at pH 7.2. |
J Med Chem 25: 435-40 (1982)
BindingDB Entry DOI: 10.7270/Q2DF6TDD |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Bos taurus (Cattle)) | BDBM50405959
(CHEMBL31912)Show InChI InChI=1S/C17H24N4O/c1-2-3-4-5-10-22-15-8-6-13(7-9-15)11-14-12-20-17(19)21-16(14)18/h6-9,12H,2-5,10-11H2,1H3,(H4,18,19,20,21) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 2.82E+3 | n/a | n/a | n/a | n/a | n/a | n/a | 7.2 | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of H-Ras-mediated farnesylation expressed in mouse NIH3T3 cells |
J Med Chem 25: 435-40 (1982)
BindingDB Entry DOI: 10.7270/Q2DF6TDD |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50405959
(CHEMBL31912)Show InChI InChI=1S/C17H24N4O/c1-2-3-4-5-10-22-15-8-6-13(7-9-15)11-14-12-20-17(19)21-16(14)18/h6-9,12H,2-5,10-11H2,1H3,(H4,18,19,20,21) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 1.95E+4 | n/a | n/a | n/a | n/a | n/a | n/a | 7.2 | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity against chicken Dihydrofolate reductase at pH 7.2. |
J Med Chem 25: 435-40 (1982)
BindingDB Entry DOI: 10.7270/Q2DF6TDD |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50405959
(CHEMBL31912)Show InChI InChI=1S/C17H24N4O/c1-2-3-4-5-10-22-15-8-6-13(7-9-15)11-14-12-20-17(19)21-16(14)18/h6-9,12H,2-5,10-11H2,1H3,(H4,18,19,20,21) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 1.95E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pomona College
Curated by ChEMBL
| Assay Description Inhibitory activity against chicken liver dihydrofolate reductase |
J Med Chem 32: 1895-905 (1989)
BindingDB Entry DOI: 10.7270/Q2QR4ZB9 |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50405959
(CHEMBL31912)Show InChI InChI=1S/C17H24N4O/c1-2-3-4-5-10-22-15-8-6-13(7-9-15)11-14-12-20-17(19)21-16(14)18/h6-9,12H,2-5,10-11H2,1H3,(H4,18,19,20,21) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 1.95E+4 | n/a | n/a | n/a | n/a | n/a | n/a | 7.2 | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity against chicken Dihydrofolate reductase at pH 7.2. |
J Med Chem 25: 435-40 (1982)
BindingDB Entry DOI: 10.7270/Q2DF6TDD |
More data for this Ligand-Target Pair | |