BDBM50457831 CHEMBL4207464
SMILES: Cn1cnc(c1)-c1ccc(OC2CCN(CC2)C(=O)Cc2ccc(OC(F)(F)F)c(F)c2)c(c1)C(N)=O
InChI Key: InChIKey=HIDHDSBYUFLSPQ-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM50457831![]() (CHEMBL4207464) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Antagonist activity at prolink-tagged TrkA in human U2OS cells assessed as inhibition of beta-NGF-induced receptor phosphorylation by measuring reduc... | J Med Chem 61: 6779-6800 (2018) Article DOI: 10.1021/acs.jmedchem.8b00633 BindingDB Entry DOI: 10.7270/Q2K64MPW | |||||||||||
More data for this Ligand-Target Pair |