BDBM50457835 CHEMBL4208638

SMILES: CC(C)(CO)Oc1ccc(C(N)=O)c(O[C@@H]2CCN(C[C@@H]2F)C(=O)Cc2ccc(OC(F)(F)F)cc2)c1

InChI Key: InChIKey=BXMJIORHIRNWCP-VQTJNVASSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50457835   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
1,3-beta-glucan synthase component GLS2 (Saccharomyces cerevisiae)	BDBM50457835 (CHEMBL4208638) Show SMILES CC(C)(CO)Oc1ccc(C(N)=O)c(O[C@@H]2CCN(C[C@@H]2F)C(=O)Cc2ccc(OC(F)(F)F)cc2)c1 |r| Show InChI InChI=1S/C25H28F4N2O6/c1-24(2,14-32)36-17-7-8-18(23(30)34)21(12-17)35-20-9-10-31(13-19(20)26)22(33)11-15-3-5-16(6-4-15)37-25(27,28)29/h3-8,12,19-20,32H,9-11,13-14H2,1-2H3,(H2,30,34)/t19-,20+/m0/s1	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human ERG by fluorescence polarization assay				J Med Chem 61: 6779-6800 (2018) Article DOI: 10.1021/acs.jmedchem.8b00633 BindingDB Entry DOI: 10.7270/Q2K64MPW
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50457835 (CHEMBL4208638) Show SMILES CC(C)(CO)Oc1ccc(C(N)=O)c(O[C@@H]2CCN(C[C@@H]2F)C(=O)Cc2ccc(OC(F)(F)F)cc2)c1 |r| Show InChI InChI=1S/C25H28F4N2O6/c1-24(2,14-32)36-17-7-8-18(23(30)34)21(12-17)35-20-9-10-31(13-19(20)26)22(33)11-15-3-5-16(6-4-15)37-25(27,28)29/h3-8,12,19-20,32H,9-11,13-14H2,1-2H3,(H2,30,34)/t19-,20+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at prolink-tagged TrkA in human U2OS cells assessed as inhibition of beta-NGF-induced receptor phosphorylation by measuring reduc...				J Med Chem 61: 6779-6800 (2018) Article DOI: 10.1021/acs.jmedchem.8b00633 BindingDB Entry DOI: 10.7270/Q2K64MPW
					More data for this Ligand-Target Pair