null

SMILES: CCc1c([nH]c2ccc(cc12)C(F)(F)F)C(=O)NC(CO)Cc1ccccc1

InChI Key: InChIKey=QNHQLBLUWHLFSC-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50457925   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50457925 (CHEMBL4207316) Show SMILES CCc1c([nH]c2ccc(cc12)C(F)(F)F)C(=O)NC(CO)Cc1ccccc1 Show InChI InChI=1S/C21H21F3N2O2/c1-2-16-17-11-14(21(22,23)24)8-9-18(17)26-19(16)20(28)25-15(12-27)10-13-6-4-3-5-7-13/h3-9,11,15,26-27H,2,10,12H2,1H3,(H,25,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
Aljouf University Curated by ChEMBL					Assay Description Inhibition of His6-tagged EGFR (unknown origin) cytoplasmic domain expressed in baculovirus infected Sf9 insect cells after 10 mins followed by addit...				Eur J Med Chem 146: 260-273 (2018) Article DOI: 10.1016/j.ejmech.2018.01.042 BindingDB Entry DOI: 10.7270/Q25X2CKD
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Mus musculus)	BDBM50457925 (CHEMBL4207316) Show SMILES CCc1c([nH]c2ccc(cc12)C(F)(F)F)C(=O)NC(CO)Cc1ccccc1 Show InChI InChI=1S/C21H21F3N2O2/c1-2-16-17-11-14(21(22,23)24)8-9-18(17)26-19(16)20(28)25-15(12-27)10-13-6-4-3-5-7-13/h3-9,11,15,26-27H,2,10,12H2,1H3,(H,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Aljouf University Curated by ChEMBL					Assay Description Inhibition of mouse full-length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...				Eur J Med Chem 146: 260-273 (2018) Article DOI: 10.1016/j.ejmech.2018.01.042 BindingDB Entry DOI: 10.7270/Q25X2CKD
					More data for this Ligand-Target Pair