null
SMILES: CC(C)CC[C@@H](N1CC[C@@H](CC(O)=O)C(F)(F)[C@H]1c1ccc(cc1)C(F)(F)F)c1ccc(cc1)C(F)(F)F
InChI Key: InChIKey=IXJFVESNZKJMSK-WMTXJRDZSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Presenilin-1 (Homo sapiens (Human)) | BDBM50481373 (CHEMBL593742) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 710 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of gamma secretase in human SHSY5Y cells expressing wild-type APP assessed as inhibition of intracellular amyloid beta-42 by electrochemil... | Bioorg Med Chem Lett 20: 755-8 (2010) Article DOI: 10.1016/j.bmcl.2009.11.034 BindingDB Entry DOI: 10.7270/Q2611347 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50481373 (CHEMBL593742) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of gamma secretase in human SHSY5Y cells expressing wild-type APP assessed as inhibition of intracellular amyloid beta-40 by electrochemil... | Bioorg Med Chem Lett 20: 755-8 (2010) Article DOI: 10.1016/j.bmcl.2009.11.034 BindingDB Entry DOI: 10.7270/Q2611347 | |||||||||||
More data for this Ligand-Target Pair |