null

SMILES: CC(C)CC[C@@H](N1CC[C@@H](CC(O)=O)C(F)(F)[C@H]1c1ccc(cc1)C(F)(F)F)c1ccc(cc1)C(F)(F)F

InChI Key: InChIKey=IXJFVESNZKJMSK-WMTXJRDZSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50481373   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Presenilin-1 (Homo sapiens (Human))	BDBM50481373 (CHEMBL593742) Show SMILES CC(C)CC[C@@H](N1CC[C@@H](CC(O)=O)C(F)(F)[C@H]1c1ccc(cc1)C(F)(F)F)c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C27H29F8NO2/c1-16(2)3-12-22(17-4-8-19(9-5-17)26(30,31)32)36-14-13-21(15-23(37)38)25(28,29)24(36)18-6-10-20(11-7-18)27(33,34)35/h4-11,16,21-22,24H,3,12-15H2,1-2H3,(H,37,38)/t21-,22+,24+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	710	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of gamma secretase in human SHSY5Y cells expressing wild-type APP assessed as inhibition of intracellular amyloid beta-42 by electrochemil...				Bioorg Med Chem Lett 20: 755-8 (2010) Article DOI: 10.1016/j.bmcl.2009.11.034 BindingDB Entry DOI: 10.7270/Q2611347
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50481373 (CHEMBL593742) Show SMILES CC(C)CC[C@@H](N1CC[C@@H](CC(O)=O)C(F)(F)[C@H]1c1ccc(cc1)C(F)(F)F)c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C27H29F8NO2/c1-16(2)3-12-22(17-4-8-19(9-5-17)26(30,31)32)36-14-13-21(15-23(37)38)25(28,29)24(36)18-6-10-20(11-7-18)27(33,34)35/h4-11,16,21-22,24H,3,12-15H2,1-2H3,(H,37,38)/t21-,22+,24+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of gamma secretase in human SHSY5Y cells expressing wild-type APP assessed as inhibition of intracellular amyloid beta-40 by electrochemil...				Bioorg Med Chem Lett 20: 755-8 (2010) Article DOI: 10.1016/j.bmcl.2009.11.034 BindingDB Entry DOI: 10.7270/Q2611347
					More data for this Ligand-Target Pair