BDBM50503235 CHEMBL4550037
SMILES: NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2nc(N)ccc2Cl)n(n1)-c1ccccc1
InChI Key: InChIKey=VCLZIRZHMACRQP-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM50503235![]() (CHEMBL4550037) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Antagonist activity at prolink-tagged TrkA (unknown origin) expressed in cells assessed as inhibition of NGF-induced receptor phosphorylation by meas... | J Med Chem 62: 247-265 (2019) Article DOI: 10.1021/acs.jmedchem.8b00280 | |||||||||||
More data for this Ligand-Target Pair |