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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM50503235'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM50503235
PNG
(CHEMBL4550037)
Show SMILES NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2nc(N)ccc2Cl)n(n1)-c1ccccc1
Show InChI InChI=1S/C22H16Cl2N6O2/c23-15-7-6-12(20-16(24)8-9-18(25)27-20)10-14(15)22(32)28-19-11-17(21(26)31)29-30(19)13-4-2-1-3-5-13/h1-11H,(H2,25,27)(H2,26,31)(H,28,32)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 16n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at prolink-tagged TrkA (unknown origin) expressed in cells assessed as inhibition of NGF-induced receptor phosphorylation by meas...

J Med Chem 62: 247-265 (2019)


Article DOI: 10.1021/acs.jmedchem.8b00280
BindingDB Entry DOI: 10.7270/Q2QR51CZ
More data for this
Ligand-Target Pair