BDBM50520121 CHEMBL4441671::US10844044, Example 1
SMILES: Cc1nc(F)ccc1-c1cc(Cn2ccn(C)c2=N)cc(c1)C(=O)NCc1ccc(Cl)c(Cl)c1
InChI Key: InChIKey=ZPVQIJIWGMKMQN-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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WD repeat-containing protein 5 (WDR5) (Homo sapiens (Human)) | BDBM50520121 (CHEMBL4441671 | US10844044, Example 1) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | PDB Article PubMed | 0.0440 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Frederick National Laboratory for Cancer Research Curated by ChEMBL | Assay Description Competitive inhibition of human N-terminal His6-SUMO tagged WDR5 (22 to 334 residues) expressed in Escherichia coli BL21-Gold(DE3) cells using 10-mer... | J Med Chem 63: 656-675 (2020) Article DOI: 10.1021/acs.jmedchem.9b01608 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
WD repeat-containing protein 5 (WDR5) (Homo sapiens (Human)) | BDBM50520121 (CHEMBL4441671 | US10844044, Example 1) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | PDB US Patent | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University US Patent | Assay Description A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo... | US Patent US10844044 (2020) | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |