Reaction Details |
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Target | WD repeat-containing protein 5 |
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Ligand | BDBM50520121 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1879085 (CHEMBL4380479) |
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Ki | 0.044000±n/a nM |
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Citation | Tian, J; Teuscher, KB; Aho, ER; Alvarado, JR; Mills, JJ; Meyers, KM; Gogliotti, RD; Han, C; Macdonald, JD; Sai, J; Shaw, JG; Sensintaffar, JL; Zhao, B; Rietz, TA; Thomas, LR; Payne, WG; Moore, WJ; Stott, GM; Kondo, J; Inoue, M; Coffey, RJ; Tansey, WP; Stauffer, SR; Lee, T; Fesik, SW Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core. J Med Chem63:656-675 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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WD repeat-containing protein 5 |
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Name: | WD repeat-containing protein 5 |
Synonyms: | BIG3 | WD repeat-containing protein 5 | WD repeat-containing protein 5 (WDR5) | WD repeat-containing protein 5 (WRD5) | WDR5 | WDR5_HUMAN |
Type: | Protein |
Mol. Mass.: | 36597.13 |
Organism: | Homo sapiens (Human) |
Description: | P61964 |
Residue: | 334 |
Sequence: | MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL
ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK
CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN
RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL
WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH
TDVVISTACHPTENIIASAALENDKTIKLWKSDC
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BDBM50520121 |
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n/a |
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Name | BDBM50520121 |
Synonyms: | CHEMBL4441671 | US10844044, Example 1 |
Type | Small organic molecule |
Emp. Form. | C25H22Cl2FN5O |
Mol. Mass. | 498.379 |
SMILES | Cc1nc(F)ccc1-c1cc(Cn2ccn(C)c2=N)cc(c1)C(=O)NCc1ccc(Cl)c(Cl)c1 |
Structure |
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