BDBM50520633 CHEMBL4448353

SMILES: CN(C)CCCNc1ccc(NCCCN(C)C)c2C(=O)c3cc(ccc3C(=O)c12)C(=O)Nc1ccc(cc1)S(C)(=O)=O

InChI Key: InChIKey=UOXMYXZGJYUAIN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50520633   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA topoisomerase II (Homo sapiens (Human))	BDBM50520633 (CHEMBL4448353) Show SMILES CN(C)CCCNc1ccc(NCCCN(C)C)c2C(=O)c3cc(ccc3C(=O)c12)C(=O)Nc1ccc(cc1)S(C)(=O)=O Show InChI InChI=1S/C32H39N5O5S/c1-36(2)18-6-16-33-26-14-15-27(34-17-7-19-37(3)4)29-28(26)30(38)24-13-8-21(20-25(24)31(29)39)32(40)35-22-9-11-23(12-10-22)43(5,41)42/h8-15,20,33-34H,6-7,16-19H2,1-5H3,(H,35,40)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.34E+3	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Poison activity at recombinant human topoisomerase 2beta using pBR322 plasmid as substrate after 30 mins by ethidium bromide staining based agarose g...				J Med Chem 61: 8947-8980 (2018) Article DOI: 10.1021/acs.jmedchem.7b01202
					More data for this Ligand-Target Pair