BDBM50521627 CHEMBL4450651

SMILES: CCN1CCN(CC1)c1cc(Nc2ncc(s2)C2=CCN(CC2)C(=O)Nc2cc(CC)on2)nc(C)n1

InChI Key: InChIKey=XOSHNFWHVQJBGN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50521627   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50521627 (CHEMBL4450651) Show SMILES CCN1CCN(CC1)c1cc(Nc2ncc(s2)C2=CCN(CC2)C(=O)Nc2cc(CC)on2)nc(C)n1 |t:19| Show InChI InChI=1S/C25H33N9O2S/c1-4-19-14-22(31-36-19)30-25(35)34-8-6-18(7-9-34)20-16-26-24(37-20)29-21-15-23(28-17(3)27-21)33-12-10-32(5-2)11-13-33/h6,14-16H,4-5,7-13H2,1-3H3,(H,30,31,35)(H,26,27,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	82	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal 6x-His-tagged c-KIT (547 to 935 residues)/(694 to 753 residues deletion) expressed in baculovirus infected...				J Med Chem 62: 3940-3957 (2019) Article DOI: 10.1021/acs.jmedchem.8b01845
					More data for this Ligand-Target Pair