BDBM50526727 CHEMBL4568508::US10807974, Example 100::US10995088, Example 100

SMILES: CS(=O)(=O)c1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1ccccc1

InChI Key: InChIKey=HQPYHGXLGJSYMM-UHFFFAOYSA-N

Data: 13 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50526727   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysyl oxidase homolog 2 (Homo sapiens (Human))	BDBM50526727 (CHEMBL4568508 | US10807974, Example 100 | US109950...) Show SMILES CS(=O)(=O)c1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1ccccc1 Show InChI InChI=1S/C17H16N2O4S3/c1-25(20,21)14-7-13(12-5-3-2-4-6-12)8-15(9-14)26(22,23)17-11-19-16(10-18)24-17/h2-9,11H,10,18H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	587	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of human C-terminal His10-tagged LOXL2 (Met1 to Gln774 residues) expressed in mouse NS0 cells using cadaverine hydrochloride as substrate ...				J Med Chem 63: 2308-2324 (2020) Article DOI: 10.1021/acs.jmedchem.9b01112
					More data for this Ligand-Target Pair
Lysyl oxidase homolog 2 (Homo sapiens (Human))	BDBM50526727 (CHEMBL4568508 | US10807974, Example 100 | US109950...) Show SMILES CS(=O)(=O)c1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1ccccc1 Show InChI InChI=1S/C17H16N2O4S3/c1-25(20,21)14-7-13(12-5-3-2-4-6-12)8-15(9-14)26(22,23)17-11-19-16(10-18)24-17/h2-9,11H,10,18H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	69	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of human C-terminal His10-tagged LOXL2 (Met1 to Gln774 residues) expressed in mouse NS0 cells using cadaverine hydrochloride as substrate ...				J Med Chem 63: 2308-2324 (2020) Article DOI: 10.1021/acs.jmedchem.9b01112
					More data for this Ligand-Target Pair
Amine oxidase [flavin-containing] B (Homo sapiens (Human))	BDBM50526727 (CHEMBL4568508 | US10807974, Example 100 | US109950...) Show SMILES CS(=O)(=O)c1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1ccccc1 Show InChI InChI=1S/C17H16N2O4S3/c1-25(20,21)14-7-13(12-5-3-2-4-6-12)8-15(9-14)26(22,23)17-11-19-16(10-18)24-17/h2-9,11H,10,18H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of recombinant human MAOB expressed in baculovirus infected BTI insect cells using luminogenic MAO substrate measured after 1 hr by MAO-gl...				J Med Chem 63: 2308-2324 (2020) Article DOI: 10.1021/acs.jmedchem.9b01112
					More data for this Ligand-Target Pair
Amine oxidase, copper containing (Homo sapiens (Human))	BDBM50526727 (CHEMBL4568508 | US10807974, Example 100 | US109950...) Show SMILES CS(=O)(=O)c1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1ccccc1 Show InChI InChI=1S/C17H16N2O4S3/c1-25(20,21)14-7-13(12-5-3-2-4-6-12)8-15(9-14)26(22,23)17-11-19-16(10-18)24-17/h2-9,11H,10,18H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of recombinant human SSAO expressed in CHO cells using luminogenic MAO substrate measured after 1 hr by MAO-glo assay				J Med Chem 63: 2308-2324 (2020) Article DOI: 10.1021/acs.jmedchem.9b01112
					More data for this Ligand-Target Pair
1,3-beta-glucan synthase component GLS2 (Saccharomyces cerevisiae)	BDBM50526727 (CHEMBL4568508 | US10807974, Example 100 | US109950...) Show SMILES CS(=O)(=O)c1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1ccccc1 Show InChI InChI=1S/C17H16N2O4S3/c1-25(20,21)14-7-13(12-5-3-2-4-6-12)8-15(9-14)26(22,23)17-11-19-16(10-18)24-17/h2-9,11H,10,18H2,1H3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of human ERG expressed in CHOK1 cells by Qpatch electrophysiological assay				J Med Chem 63: 2308-2324 (2020) Article DOI: 10.1021/acs.jmedchem.9b01112
					More data for this Ligand-Target Pair
D-Amino Acid Oxidase (DAAO) (Sus scrofa (pig))	BDBM50526727 (CHEMBL4568508 | US10807974, Example 100 | US109950...) Show SMILES CS(=O)(=O)c1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1ccccc1 Show InChI InChI=1S/C17H16N2O4S3/c1-25(20,21)14-7-13(12-5-3-2-4-6-12)8-15(9-14)26(22,23)17-11-19-16(10-18)24-17/h2-9,11H,10,18H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of porcine kidney DAO measured after 1 hrs by ROS-glo assay				J Med Chem 63: 2308-2324 (2020) Article DOI: 10.1021/acs.jmedchem.9b01112
					More data for this Ligand-Target Pair
D-amino-acid oxidase (Homo sapiens (Human))	BDBM50526727 (CHEMBL4568508 | US10807974, Example 100 | US109950...) Show SMILES CS(=O)(=O)c1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1ccccc1 Show InChI InChI=1S/C17H16N2O4S3/c1-25(20,21)14-7-13(12-5-3-2-4-6-12)8-15(9-14)26(22,23)17-11-19-16(10-18)24-17/h2-9,11H,10,18H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL US Patent					Assay Description ReagentsPromega ROS-Glo H2O2 Assay Kit, 50 ml. Cat No. G8821Inhibitors (Test Compounds):10 mM stock diluted to 10, 3, 1, 0.3, 0.1, 0.03, 0.01, 0.003,...				US Patent US10995088 (2021)
					More data for this Ligand-Target Pair
Amine oxidase (flavin-containing) A (Homo sapiens (Human))	BDBM50526727 (CHEMBL4568508 | US10807974, Example 100 | US109950...) Show SMILES CS(=O)(=O)c1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1ccccc1 Show InChI InChI=1S/C17H16N2O4S3/c1-25(20,21)14-7-13(12-5-3-2-4-6-12)8-15(9-14)26(22,23)17-11-19-16(10-18)24-17/h2-9,11H,10,18H2,1H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.93E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of recombinant human MAOA expressed in baculovirus infected BTI insect cells using luminogenic MAO substrate measured after 1 hr by MAO-gl...				J Med Chem 63: 2308-2324 (2020) Article DOI: 10.1021/acs.jmedchem.9b01112
					More data for this Ligand-Target Pair
Lysyl oxidase homolog 2 (Homo sapiens (Human))	BDBM50526727 (CHEMBL4568508 | US10807974, Example 100 | US109950...) Show SMILES CS(=O)(=O)c1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1ccccc1 Show InChI InChI=1S/C17H16N2O4S3/c1-25(20,21)14-7-13(12-5-3-2-4-6-12)8-15(9-14)26(22,23)17-11-19-16(10-18)24-17/h2-9,11H,10,18H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	86	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of human C-terminal His10-tagged LOXL2 (Met1 to Gln774 residues) expressed in mouse NS0 cells using cadaverine hydrochloride as substrate ...				J Med Chem 63: 2308-2324 (2020) Article DOI: 10.1021/acs.jmedchem.9b01112
					More data for this Ligand-Target Pair
Lysyl oxidase homolog 2 (Homo sapiens (Human))	BDBM50526727 (CHEMBL4568508 | US10807974, Example 100 | US109950...) Show SMILES CS(=O)(=O)c1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1ccccc1 Show InChI InChI=1S/C17H16N2O4S3/c1-25(20,21)14-7-13(12-5-3-2-4-6-12)8-15(9-14)26(22,23)17-11-19-16(10-18)24-17/h2-9,11H,10,18H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research: Royal Cancer Hospital US Patent					Assay Description LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 20 hours at room temp on a plate shaker.				US Patent US10807974 (2020)
					More data for this Ligand-Target Pair
Diamine oxidase (Homo sapiens (Human))	BDBM50526727 (CHEMBL4568508 | US10807974, Example 100 | US109950...) Show SMILES CS(=O)(=O)c1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1ccccc1 Show InChI InChI=1S/C17H16N2O4S3/c1-25(20,21)14-7-13(12-5-3-2-4-6-12)8-15(9-14)26(22,23)17-11-19-16(10-18)24-17/h2-9,11H,10,18H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research: Royal Cancer Hospital US Patent					Assay Description Promega ROS-Glo H2O2 Assay Kit, 50 ml. Cat No. G8821.				US Patent US10807974 (2020)
					More data for this Ligand-Target Pair
Lysyl oxidase homolog 2 (Homo sapiens (Human))	BDBM50526727 (CHEMBL4568508 | US10807974, Example 100 | US109950...) Show SMILES CS(=O)(=O)c1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1ccccc1 Show InChI InChI=1S/C17H16N2O4S3/c1-25(20,21)14-7-13(12-5-3-2-4-6-12)8-15(9-14)26(22,23)17-11-19-16(10-18)24-17/h2-9,11H,10,18H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL US Patent					Assay Description 10. Incubate for 20 hrs at room temp on a plate shaker, protected from light.				US Patent US10995088 (2021)
					More data for this Ligand-Target Pair
Lysyl oxidase homolog 3 (Homo sapiens (Human))	BDBM50526727 (CHEMBL4568508 | US10807974, Example 100 | US109950...) Show SMILES CS(=O)(=O)c1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1ccccc1 Show InChI InChI=1S/C17H16N2O4S3/c1-25(20,21)14-7-13(12-5-3-2-4-6-12)8-15(9-14)26(22,23)17-11-19-16(10-18)24-17/h2-9,11H,10,18H2,1H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	860	n/a	n/a	n/a	n/a	n/a	n/a
University of Manchester Curated by ChEMBL					Assay Description Inhibition of recombinant C-terminal His-tagged human LOXL3 (1 to 753 residues) expressed in CHO cells using cadaverine hydrochloride as substrate pr...				J Med Chem 63: 2308-2324 (2020) Article DOI: 10.1021/acs.jmedchem.9b01112
					More data for this Ligand-Target Pair