BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 33 hits Enz. Inhib. hit(s) with Target = 'Lysyl oxidase homolog 3'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Lysyl oxidase homolog 3


(Homo sapiens (Human))		BDBM50505638
PNG
(CHEMBL4457578)
Show SMILES Cl.CN(C)S(=O)(=O)c1cccc(c1)-c1c(C)n(C\C(F)=C\CN)c2ccc(cc12)C(O)=O
Show InChI InChI=1S/C22H24FN3O4S/c1-14-21(15-5-4-6-18(11-15)31(29,30)25(2)3)19-12-16(22(27)28)7-8-20(19)26(14)13-17(23)9-10-24/h4-9,11-12H,10,13,24H2,1-3H3,(H,27,28)/b17-9-
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 16n/an/an/an/an/an/a



Pharmaxis Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant C-terminal His-tagged human LOXL3 (1 to 753 residues) expressed in CHO cells using putrescine as substrate preincubated wit...

J Med Chem 62: 9874-9889 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01283
BindingDB Entry DOI: 10.7270/Q2VM4GJ2
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 3


(Homo sapiens (Human))		BDBM50058655
PNG
(1,1',1'',1'''-[disulfanediylbis(carbonothioylnitri...)
Show SMILES CCN(CC)C(=S)SSC(=S)N(CC)CC
Show InChI InChI=1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MCE
KEGG
PC cid
PC sid
UniChem

Patents
Article
PubMed
n/an/a 93n/an/an/an/an/an/a



Hungarian Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant human LOXL3 expressed in CHO cells using diaminopentane as substrate preincubated for 30 mins followed by substrate additio...

Bioorg Med Chem Lett 28: 3113-3118 (2018)


Article DOI: 10.1016/j.bmcl.2018.07.001
BindingDB Entry DOI: 10.7270/Q28P6366
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 3


(Homo sapiens (Human))		BDBM43362
PNG
(MLS000069752 | N,N-dimethylcarbamodithioic acid (d...)
Show SMILES CN(C)C(=S)SSC(=S)N(C)C
Show InChI InChI=1S/C6H12N2S4/c1-7(2)5(9)11-12-6(10)8(3)4/h1-4H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

KEGG
PC cid
PC sid
UniChem

Patents
Article
PubMed
n/an/a 110n/an/an/an/an/an/a



Hungarian Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant human LOXL3 expressed in CHO cells using diaminopentane as substrate preincubated for 30 mins followed by substrate additio...

Bioorg Med Chem Lett 28: 3113-3118 (2018)


Article DOI: 10.1016/j.bmcl.2018.07.001
BindingDB Entry DOI: 10.7270/Q28P6366
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 3


(Homo sapiens (Human))		BDBM50232678
PNG
(CHEBI:27413 | CHEMBL1618272 | US10717734, Compound...)
Show InChI InChI=1S/C3H6N2/c4-2-1-3-5/h1-2,4H2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
KEGG
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 170n/an/an/an/an/an/a



Hungarian Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant human LOXL3 expressed in CHO cells using diaminopentane as substrate preincubated for 30 mins followed by substrate additio...

Bioorg Med Chem Lett 28: 3113-3118 (2018)


Article DOI: 10.1016/j.bmcl.2018.07.001
BindingDB Entry DOI: 10.7270/Q28P6366
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 3


(Homo sapiens (Human))		BDBM50232679
PNG
(CHEMBL4068784 | US11358936, Compound 4-5)
Show SMILES NCc1ccnc(Cl)c1
Show InChI InChI=1S/C6H7ClN2/c7-6-3-5(4-8)1-2-9-6/h1-3H,4,8H2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 214n/an/an/an/an/an/a



PharmAkea Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human C-terminal His10-tagged LOXL3 (1 to 753 residues) assessed as reduction in H2O2 production using DAP as substrate pre...

ACS Med Chem Lett 8: 423-427 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00014
BindingDB Entry DOI: 10.7270/Q2542QV6
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 3


(Homo sapiens (Human))		BDBM633246
PNG
((3aS,3a'S,4S,4'S,6aR,6a′R)-4,4′-(((((5...)
Show SMILES NC\C=C(/F)CS(=O)(=O)c1cccc(Cn2cc(nn2)-c2cc(OCCCc3cn(CCCCC[C@@H]4SC[C@@H]5NC(=O)N[C@H]45)nn3)cc(OCCCc3cn(CCCCC[C@@H]4SC[C@@H]5NC(=O)N[C@H]45)nn3)c2)c1 |r|
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a>300n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 3


(Homo sapiens (Human))		BDBM633249
PNG
(N-((1-(4-(((1-((Z)-4-amino-2-fluorobut-2-en-1-yl)-...)
Show SMILES CN(C)S(=O)(=O)c1ccc(cc1)C(OCc1ccc(cc1)-n1cc(CNC(=O)CCCC[C@@H]2SC[C@@H]3NC(=O)N[C@H]23)nn1)c1cn(C\C(F)=C\CN)nn1 |r,w:13.13|
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a<300n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 3


(Homo sapiens (Human))		BDBM50232678
PNG
(CHEBI:27413 | CHEMBL1618272 | US10717734, Compound...)
Show InChI InChI=1S/C3H6N2/c4-2-1-3-5/h1-2,4H2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
KEGG
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 310n/an/an/an/an/an/a



University of Manchester

Curated by ChEMBL


Assay Description
Inhibition of recombinant C-terminal His-tagged human LOXL3 (1 to 753 residues) expressed in CHO cells using cadaverine hydrochloride as substrate pr...

J Med Chem 63: 2308-2324 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01112
BindingDB Entry DOI: 10.7270/Q2J38X0T
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 3


(Homo sapiens (Human))		BDBM50526727
PNG
(CHEMBL4568508 | US10807974, Example 100 | US109950...)
Show SMILES CS(=O)(=O)c1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1ccccc1
Show InChI InChI=1S/C17H16N2O4S3/c1-25(20,21)14-7-13(12-5-3-2-4-6-12)8-15(9-14)26(22,23)17-11-19-16(10-18)24-17/h2-9,11H,10,18H2,1H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 860n/an/an/an/an/an/a



University of Manchester

Curated by ChEMBL


Assay Description
Inhibition of recombinant C-terminal His-tagged human LOXL3 (1 to 753 residues) expressed in CHO cells using cadaverine hydrochloride as substrate pr...

J Med Chem 63: 2308-2324 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01112
BindingDB Entry DOI: 10.7270/Q2J38X0T
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 3


(Homo sapiens (Human))		BDBM50266786
PNG
(CHEMBL4063337)
Show SMILES Cl.NCc1ccnc(Oc2cccc(c2)C(=O)N2C[C@@H](O)[C@H](F)C2)c1 |r|
Show InChI InChI=1S/C17H18FN3O3.ClH/c18-14-9-21(10-15(14)22)17(23)12-2-1-3-13(7-12)24-16-6-11(8-19)4-5-20-16;/h1-7,14-15,22H,8-10,19H2;1H/t14-,15-;/m1./s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.17E+3n/an/an/an/an/an/a



PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of recombinant human LOXL3 assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs followed by s...

J Med Chem 60: 4403-4423 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00345
BindingDB Entry DOI: 10.7270/Q2QV3Q0K
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 3


(Homo sapiens (Human))		BDBM461421
PNG
(US10774069, Compound 1 | US11072585, Example 120 |...)
Show SMILES NCc1cc(Oc2cccc(c2)C(=O)N2C[C@@H](O)[C@H](F)C2)nc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C18H17F4N3O3/c19-13-8-25(9-14(13)26)17(27)11-2-1-3-12(6-11)28-16-5-10(7-23)4-15(24-16)18(20,21)22/h1-6,13-14,26H,7-9,23H2/t13-,14-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem
n/an/a 1.21E+3n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 3


(Homo sapiens (Human))		BDBM50266787
PNG
(CHEMBL4092740)
Show SMILES Cl.NCc1ccnc(Oc2cccc(c2)C(=O)N2C[C@H](O)[C@@H](F)C2)c1 |r|
Show InChI InChI=1S/C17H18FN3O3.ClH/c18-14-9-21(10-15(14)22)17(23)12-2-1-3-13(7-12)24-16-6-11(8-19)4-5-20-16;/h1-7,14-15,22H,8-10,19H2;1H/t14-,15-;/m0./s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.22E+3n/an/an/an/an/an/a



PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of recombinant human LOXL3 assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs followed by s...

J Med Chem 60: 4403-4423 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00345
BindingDB Entry DOI: 10.7270/Q2QV3Q0K
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 3


(Homo sapiens (Human))		BDBM50526722
PNG
(CHEMBL4457897)
Show SMILES Cn1cc(cn1)-c1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)S(C)(=O)=O
Show InChI InChI=1S/C15H16N4O4S3/c1-19-9-11(7-18-19)10-3-12(25(2,20)21)5-13(4-10)26(22,23)15-8-17-14(6-16)24-15/h3-5,7-9H,6,16H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.22E+3n/an/an/an/an/an/a



University of Manchester

Curated by ChEMBL


Assay Description
Inhibition of recombinant C-terminal His-tagged human LOXL3 (1 to 753 residues) expressed in CHO cells using cadaverine hydrochloride as substrate pr...

J Med Chem 63: 2308-2324 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01112
BindingDB Entry DOI: 10.7270/Q2J38X0T
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 3


(Homo sapiens (Human))		BDBM50526721
PNG
(CHEMBL4444163 | US10807974, Example 111 | US109950...)
Show SMILES CCc1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1cnn(C)c1
Show InChI InChI=1S/C16H18N4O2S2/c1-3-11-4-12(13-8-19-20(2)10-13)6-14(5-11)24(21,22)16-9-18-15(7-17)23-16/h4-6,8-10H,3,7,17H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.25E+3n/an/an/an/an/an/a



University of Manchester

Curated by ChEMBL


Assay Description
Inhibition of recombinant C-terminal His-tagged human LOXL3 (1 to 753 residues) expressed in CHO cells using cadaverine hydrochloride as substrate pr...

J Med Chem 63: 2308-2324 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01112
BindingDB Entry DOI: 10.7270/Q2J38X0T
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 3


(Homo sapiens (Human))		BDBM50463622
PNG
(CHEMBL4245637)
Show SMILES CC1C(C)=NN(C1=O)c1ccccc1 |c:3|
Show InChI InChI=1S/C11H12N2O/c1-8-9(2)12-13(11(8)14)10-6-4-3-5-7-10/h3-8H,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.30E+3n/an/an/an/an/an/a



Hungarian Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant human LOXL3 expressed in CHO cells using diaminopentane as substrate preincubated for 30 mins followed by substrate additio...

Bioorg Med Chem Lett 28: 3113-3118 (2018)


Article DOI: 10.1016/j.bmcl.2018.07.001
BindingDB Entry DOI: 10.7270/Q28P6366
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 3


(Homo sapiens (Human))		BDBM50266822
PNG
(CHEMBL4079398)
Show SMILES Cl.NCc1cc(Oc2cccc(c2)C(=O)N2C[C@@H](O)[C@H](F)C2)nc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C18H17F4N3O3.ClH/c19-13-8-25(9-14(13)26)17(27)11-2-1-3-12(6-11)28-16-5-10(7-23)4-15(24-16)18(20,21)22;/h1-6,13-14,26H,7-9,23H2;1H/t13-,14-;/m1./s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.38E+3n/an/an/an/an/an/a



PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of recombinant human LOXL3 assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs followed by s...

J Med Chem 60: 4403-4423 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00345
BindingDB Entry DOI: 10.7270/Q2QV3Q0K
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 3


(Homo sapiens (Human))		BDBM50463620
PNG
(CHEMBL4240937)
Show SMILES CCN1\C(C=Cc2ccccc12)=C1/C(=O)N(N=C1Nc1ccccc1)c1ccccc1 |c:4,18|
Show InChI InChI=1S/C26H22N4O/c1-2-29-22-16-10-9-11-19(22)17-18-23(29)24-25(27-20-12-5-3-6-13-20)28-30(26(24)31)21-14-7-4-8-15-21/h3-18H,2H2,1H3,(H,27,28)/b24-23-
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.10E+3n/an/an/an/an/an/a



Hungarian Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant human LOXL3 expressed in CHO cells using diaminopentane as substrate preincubated for 30 mins followed by substrate additio...

Bioorg Med Chem Lett 28: 3113-3118 (2018)


Article DOI: 10.1016/j.bmcl.2018.07.001
BindingDB Entry DOI: 10.7270/Q28P6366
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 3


(Homo sapiens (Human))		BDBM50526742
PNG
(CHEMBL4441069)
Show SMILES CS(=O)(=O)c1cc(Sc2cnc(CN)s2)cc(c1)-c1ccccc1
Show InChI InChI=1S/C17H16N2O2S3/c1-24(20,21)15-8-13(12-5-3-2-4-6-12)7-14(9-15)22-17-11-19-16(10-18)23-17/h2-9,11H,10,18H2,1H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.85E+3n/an/an/an/an/an/a



University of Manchester

Curated by ChEMBL


Assay Description
Inhibition of recombinant C-terminal His-tagged human LOXL3 (1 to 753 residues) expressed in CHO cells using cadaverine hydrochloride as substrate pr...

J Med Chem 63: 2308-2324 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01112
BindingDB Entry DOI: 10.7270/Q2J38X0T
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 3


(Homo sapiens (Human))		BDBM50526720
PNG
(CHEMBL4550042)
Show SMILES CS(=O)(=O)c1cc(cc(c1)S(=O)(=O)c1csc(CN)n1)-c1ccccc1
Show InChI InChI=1S/C17H16N2O4S3/c1-25(20,21)14-7-13(12-5-3-2-4-6-12)8-15(9-14)26(22,23)17-11-24-16(10-18)19-17/h2-9,11H,10,18H2,1H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.86E+3n/an/an/an/an/an/a



University of Manchester

Curated by ChEMBL


Assay Description
Inhibition of recombinant C-terminal His-tagged human LOXL3 (1 to 753 residues) expressed in CHO cells using cadaverine hydrochloride as substrate pr...

J Med Chem 63: 2308-2324 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01112
BindingDB Entry DOI: 10.7270/Q2J38X0T
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 3


(Homo sapiens (Human))		BDBM50463614
PNG
(CHEMBL4237334)
Show SMILES O=c1n([nH]c2nc(ccc12)-c1cccs1)-c1ccccc1
Show InChI InChI=1S/C16H11N3OS/c20-16-12-8-9-13(14-7-4-10-21-14)17-15(12)18-19(16)11-5-2-1-3-6-11/h1-10H,(H,17,18)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5.00E+3n/an/an/an/an/an/a



Hungarian Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant human LOXL3 expressed in CHO cells using diaminopentane as substrate preincubated for 30 mins followed by substrate additio...

Bioorg Med Chem Lett 28: 3113-3118 (2018)


Article DOI: 10.1016/j.bmcl.2018.07.001
BindingDB Entry DOI: 10.7270/Q28P6366
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 3


(Homo sapiens (Human))		BDBM50463617
PNG
(CHEMBL4238380)
Show SMILES Cc1cc(c(C)o1)-c1ccc2c(n1)[nH]n(-c1ccccc1)c2=O
Show InChI InChI=1S/C18H15N3O2/c1-11-10-15(12(2)23-11)16-9-8-14-17(19-16)20-21(18(14)22)13-6-4-3-5-7-13/h3-10H,1-2H3,(H,19,20)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5.00E+3n/an/an/an/an/an/a



Hungarian Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant human LOXL3 expressed in CHO cells using diaminopentane as substrate preincubated for 30 mins followed by substrate additio...

Bioorg Med Chem Lett 28: 3113-3118 (2018)


Article DOI: 10.1016/j.bmcl.2018.07.001
BindingDB Entry DOI: 10.7270/Q28P6366
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 3


(Homo sapiens (Human))		BDBM50526726
PNG
(CHEMBL4574361)
Show SMILES Cn1cc(cn1)-c1cc(cc(c1)S(=O)(=O)c1csc(CN)n1)S(C)(=O)=O
Show InChI InChI=1S/C15H16N4O4S3/c1-19-8-11(7-17-19)10-3-12(25(2,20)21)5-13(4-10)26(22,23)15-9-24-14(6-16)18-15/h3-5,7-9H,6,16H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6.69E+3n/an/an/an/an/an/a



University of Manchester

Curated by ChEMBL


Assay Description
Inhibition of recombinant C-terminal His-tagged human LOXL3 (1 to 753 residues) expressed in CHO cells using cadaverine hydrochloride as substrate pr...

J Med Chem 63: 2308-2324 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01112
BindingDB Entry DOI: 10.7270/Q2J38X0T
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 3


(Homo sapiens (Human))		BDBM50526731
PNG
(CHEMBL4564074 | US10807974, Example 103 | US109950...)
Show SMILES CCc1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)-c1ccccc1
Show InChI InChI=1S/C18H18N2O2S2/c1-2-13-8-15(14-6-4-3-5-7-14)10-16(9-13)24(21,22)18-12-20-17(11-19)23-18/h3-10,12H,2,11,19H2,1H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6.78E+3n/an/an/an/an/an/a



University of Manchester

Curated by ChEMBL


Assay Description
Inhibition of recombinant C-terminal His-tagged human LOXL3 (1 to 753 residues) expressed in CHO cells using cadaverine hydrochloride as substrate pr...

J Med Chem 63: 2308-2324 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01112
BindingDB Entry DOI: 10.7270/Q2J38X0T
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 3


(Homo sapiens (Human))		BDBM50526743
PNG
(CHEMBL4551909)
Show SMILES CS(=O)(=O)c1cc(cc(c1)-c1ccccc1)-c1cnc(CN)s1
Show InChI InChI=1S/C17H16N2O2S2/c1-23(20,21)15-8-13(12-5-3-2-4-6-12)7-14(9-15)16-11-19-17(10-18)22-16/h2-9,11H,10,18H2,1H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 9.31E+3n/an/an/an/an/an/a



University of Manchester

Curated by ChEMBL


Assay Description
Inhibition of recombinant C-terminal His-tagged human LOXL3 (1 to 753 residues) expressed in CHO cells using cadaverine hydrochloride as substrate pr...

J Med Chem 63: 2308-2324 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01112
BindingDB Entry DOI: 10.7270/Q2J38X0T
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 3


(Homo sapiens (Human))		BDBM50463618
PNG
(CHEMBL4241062)
Show SMILES CC1=NN(C(=O)\C1=C\NNc1nnc(C)c(O)n1)c1ccccc1 |t:1|
Show InChI InChI=1S/C15H15N7O2/c1-9-12(8-16-19-15-17-13(23)10(2)18-20-15)14(24)22(21-9)11-6-4-3-5-7-11/h3-8,16H,1-2H3,(H2,17,19,20,23)/b12-8+
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.20E+4n/an/an/an/an/an/a



Hungarian Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant human LOXL3 expressed in CHO cells using diaminopentane as substrate preincubated for 30 mins followed by substrate additio...

Bioorg Med Chem Lett 28: 3113-3118 (2018)


Article DOI: 10.1016/j.bmcl.2018.07.001
BindingDB Entry DOI: 10.7270/Q28P6366
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 3


(Homo sapiens (Human))		BDBM50366038
PNG
(CHEMBL1356238)
Show SMILES [O-][n+]1ccccc1S
Show InChI InChI=1S/C5H5NOS/c7-6-4-2-1-3-5(6)8/h1-4,8H
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MMDB
PC cid
PC sid
UniChem

Patents
Article
PubMed
n/an/a 1.20E+4n/an/an/an/an/an/a



Hungarian Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant human LOXL3 expressed in CHO cells using diaminopentane as substrate preincubated for 30 mins followed by substrate additio...

Bioorg Med Chem Lett 28: 3113-3118 (2018)


Article DOI: 10.1016/j.bmcl.2018.07.001
BindingDB Entry DOI: 10.7270/Q28P6366
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 3


(Homo sapiens (Human))		BDBM50501885
PNG
(CHEMBL4441173 | US10807974, Example 68 | US1099508...)
Show SMILES CS(=O)(=O)c1cc(cc(c1)S(=O)(=O)c1ccc(CN)s1)-c1ccccc1
Show InChI InChI=1S/C18H17NO4S3/c1-25(20,21)16-9-14(13-5-3-2-4-6-13)10-17(11-16)26(22,23)18-8-7-15(12-19)24-18/h2-11H,12,19H2,1H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.35E+4n/an/an/an/an/an/a



University of Manchester

Curated by ChEMBL


Assay Description
Inhibition of recombinant C-terminal His-tagged human LOXL3 (1 to 753 residues) expressed in CHO cells using cadaverine hydrochloride as substrate pr...

J Med Chem 63: 2308-2324 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01112
BindingDB Entry DOI: 10.7270/Q2J38X0T
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 3


(Homo sapiens (Human))		BDBM50463613
PNG
(CHEMBL1927732)
Show SMILES O=c1n(-c2ccccc2)c(=S)[nH]c2ncccc12
Show InChI InChI=1S/C13H9N3OS/c17-12-10-7-4-8-14-11(10)15-13(18)16(12)9-5-2-1-3-6-9/h1-8H,(H,14,15,18)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.80E+4n/an/an/an/an/an/a



Hungarian Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant human LOXL3 expressed in CHO cells using diaminopentane as substrate preincubated for 30 mins followed by substrate additio...

Bioorg Med Chem Lett 28: 3113-3118 (2018)


Article DOI: 10.1016/j.bmcl.2018.07.001
BindingDB Entry DOI: 10.7270/Q28P6366
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 3


(Homo sapiens (Human))		BDBM50526728
PNG
(CHEMBL4463882 | US10807974, Example 155 | US109950...)
Show SMILES CCc1cc(cc(c1)S(=O)(=O)c1csc(CN)n1)-c1cnn(C)c1
Show InChI InChI=1S/C16H18N4O2S2/c1-3-11-4-12(13-8-18-20(2)9-13)6-14(5-11)24(21,22)16-10-23-15(7-17)19-16/h4-6,8-10H,3,7,17H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.42E+4n/an/an/an/an/an/a



University of Manchester

Curated by ChEMBL


Assay Description
Inhibition of recombinant C-terminal His-tagged human LOXL3 (1 to 753 residues) expressed in CHO cells using cadaverine hydrochloride as substrate pr...

J Med Chem 63: 2308-2324 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01112
BindingDB Entry DOI: 10.7270/Q2J38X0T
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 3


(Homo sapiens (Human))		BDBM50463619
PNG
(CHEMBL4242081)
Show SMILES COc1ccccc1-c1cc(=O)c2c([nH]n(-c3ccccc3)c2=O)[nH]1
Show InChI InChI=1S/C19H15N3O3/c1-25-16-10-6-5-9-13(16)14-11-15(23)17-18(20-14)21-22(19(17)24)12-7-3-2-4-8-12/h2-11H,1H3,(H2,20,21,23)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5.70E+4n/an/an/an/an/an/a



Hungarian Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant human LOXL3 expressed in CHO cells using diaminopentane as substrate preincubated for 30 mins followed by substrate additio...

Bioorg Med Chem Lett 28: 3113-3118 (2018)


Article DOI: 10.1016/j.bmcl.2018.07.001
BindingDB Entry DOI: 10.7270/Q28P6366
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 3


(Homo sapiens (Human))		BDBM50463621
PNG
(CHEMBL3144916)
Show SMILES Cc1cc(C)c2c(n1)[nH]n(-c1ccccc1)c2=O
Show InChI InChI=1S/C14H13N3O/c1-9-8-10(2)15-13-12(9)14(18)17(16-13)11-6-4-3-5-7-11/h3-8H,1-2H3,(H,15,16)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Hungarian Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant human LOXL3 expressed in CHO cells using diaminopentane as substrate preincubated for 30 mins followed by substrate additio...

Bioorg Med Chem Lett 28: 3113-3118 (2018)


Article DOI: 10.1016/j.bmcl.2018.07.001
BindingDB Entry DOI: 10.7270/Q28P6366
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 3


(Homo sapiens (Human))		BDBM50463616
PNG
(CHEMBL4241417)
Show SMILES CC(C)(C)C1=NN(C(=O)C1)c1ccccc1 |t:4|
Show InChI InChI=1S/C13H16N2O/c1-13(2,3)11-9-12(16)15(14-11)10-7-5-4-6-8-10/h4-8H,9H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Hungarian Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant human LOXL3 expressed in CHO cells using diaminopentane as substrate preincubated for 30 mins followed by substrate additio...

Bioorg Med Chem Lett 28: 3113-3118 (2018)


Article DOI: 10.1016/j.bmcl.2018.07.001
BindingDB Entry DOI: 10.7270/Q28P6366
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 3


(Homo sapiens (Human))		BDBM50463615
PNG
(CHEMBL4251179)
Show SMILES CCOC(=O)c1sc(N\N=C2\C(N)=NN(C2=O)c2ccccc2)c(C(=O)OCC)c1C |c:12|
Show InChI InChI=1S/C20H21N5O5S/c1-4-29-19(27)13-11(3)15(20(28)30-5-2)31-17(13)23-22-14-16(21)24-25(18(14)26)12-9-7-6-8-10-12/h6-10,23H,4-5H2,1-3H3,(H2,21,24)/b22-14-
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Hungarian Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant human LOXL3 expressed in CHO cells using diaminopentane as substrate preincubated for 30 mins followed by substrate additio...

Bioorg Med Chem Lett 28: 3113-3118 (2018)


Article DOI: 10.1016/j.bmcl.2018.07.001
BindingDB Entry DOI: 10.7270/Q28P6366
More data for this
Ligand-Target Pair