null

SMILES: Cc1c-2c(nn1C)C(CCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(F)c-2c13

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 571455   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide (Homo sapiens (Human))	BDBM571455 ((rac)-4-fluoro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]...) Show SMILES Cc1c-2c(nn1C)C(CCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(F)c-2c13 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The dose-dependent inhibition by the compounds described in this invention of the interaction between MCL-1 and the BH3 domain of Noxa (both human) w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2J38WT5
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide (Homo sapiens (Human))	BDBM571455 ((rac)-4-fluoro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]...) Show SMILES Cc1c-2c(nn1C)C(CCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(F)c-2c13 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.790	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The dose-dependent inhibition by the compounds described in this invention of the interaction between MCL-1 and the BH3 domain of Noxa (both human) w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2J38WT5
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide (Homo sapiens (Human))	BDBM571455 ((rac)-4-fluoro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]...) Show SMILES Cc1c-2c(nn1C)C(CCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(F)c-2c13 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The dose-dependent inhibition by the compounds described in this invention of the interaction between MCL-1 and the BH3 domain of Noxa (both human) w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2J38WT5
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 [1-211]/Bad BH3 Peptide (Homo sapiens (Human))	BDBM571455 ((rac)-4-fluoro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]...) Show SMILES Cc1c-2c(nn1C)C(CCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(F)c-2c13 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The dose-dependent inhibition by the compounds described in this invention of the interaction between BCL-2 and the BH3 domain of Bad (both human) wa...				Citation and Details BindingDB Entry DOI: 10.7270/Q2J38WT5
					More data for this Ligand-Target Pair
Bcl-2-like protein 1 [1-212]/Bad BH3 Peptide (Homo sapiens (Human))	BDBM571455 ((rac)-4-fluoro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]...) Show SMILES Cc1c-2c(nn1C)C(CCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(F)c-2c13 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The dose-dependent inhibition by the compounds described in this invention of the interaction between BCL-XL and the BH3 domain of Bad (both human) w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2J38WT5
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 [1-211]/Bad BH3 Peptide (Homo sapiens (Human))	BDBM571455 ((rac)-4-fluoro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]...) Show SMILES Cc1c-2c(nn1C)C(CCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(F)c-2c13 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The dose-dependent inhibition by the compounds described in this invention of the interaction between BCL-2 and the BH3 domain of Bad (both human) wa...				Citation and Details BindingDB Entry DOI: 10.7270/Q2J38WT5
					More data for this Ligand-Target Pair
Bcl-2-like protein 1 [1-212]/Bad BH3 Peptide (Homo sapiens (Human))	BDBM571455 ((rac)-4-fluoro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]...) Show SMILES Cc1c-2c(nn1C)C(CCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(F)c-2c13 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The dose-dependent inhibition by the compounds described in this invention of the interaction between BCL-XL and the BH3 domain of Bad (both human) w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2J38WT5
					More data for this Ligand-Target Pair
Bcl-2-like protein 1 [1-212]/Bad BH3 Peptide (Homo sapiens (Human))	BDBM571455 ((rac)-4-fluoro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]...) Show SMILES Cc1c-2c(nn1C)C(CCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(F)c-2c13 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The dose-dependent inhibition by the compounds described in this invention of the interaction between BCL-XL and the BH3 domain of Bad (both human) w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2J38WT5
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 [1-211]/Bad BH3 Peptide (Homo sapiens (Human))	BDBM571455 ((rac)-4-fluoro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]...) Show SMILES Cc1c-2c(nn1C)C(CCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(F)c-2c13 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The dose-dependent inhibition by the compounds described in this invention of the interaction between BCL-2 and the BH3 domain of Bad (both human) wa...				Citation and Details BindingDB Entry DOI: 10.7270/Q2J38WT5
					More data for this Ligand-Target Pair