null
SMILES: CCCCCC[C@H]1CCc2cc([C@H]3CC[C@](N)(COP(O)(O)=O)C3)c(C)cc2C1
InChI Key: InChIKey=HWJQVZJSCVHGIW-GREBRCKQSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sphingosine 1-phosphate receptor 1 (Homo sapiens (Human)) | BDBM65304 (US10166249, Example 622 | US9522888, 622) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Bristol-Myers Squibb Company US Patent | Assay Description Membranes were prepared from CHO cells expressing human S1P1. Cells pellets (1x10^9 cells/pellet) were suspended in buffer containing 20 mM HEPES (4-... | US Patent US9522888 (2016) BindingDB Entry DOI: 10.7270/Q20K27HV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sphingosine 1-phosphate receptor 1 (Homo sapiens (Human)) | BDBM65304 (US10166249, Example 622 | US9522888, 622) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | n/a | 60 |
Bristol-Myers Squibb Company US Patent | Assay Description Compounds were loaded in a 384 Falcon v-bottom plate (0.5 ul/well in a 11 point, 3-fold dilution). Membranes prepared from S1P1/CHO cells or EDG3-Gal... | US Patent US9522888 (2016) BindingDB Entry DOI: 10.7270/Q20K27HV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sphingosine 1-phosphate receptor 3 (Homo sapiens (Human)) | BDBM65304 (US10166249, Example 622 | US9522888, 622) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >625 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description Compounds were loaded in a 384 Falcon v-bottom plate (0.5 l/well in a 11 point, 3-fold dilution). Membranes prepared from S1P1/CHO cells or EDG3-Gal5... | US Patent US10166249 (2019) BindingDB Entry DOI: 10.7270/Q2S75JCM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sphingosine-1-phosphate lyase 1 (Homo sapiens (Human)) | BDBM65304 (US10166249, Example 622 | US9522888, 622) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description Membranes were prepared from CHO cells expressing human S1P1. Cells pellets (1×109 cells/pellet) were suspended in buffer containing 20 mM HEPES (4-(... | US Patent US10166249 (2019) BindingDB Entry DOI: 10.7270/Q2S75JCM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sphingosine-1-phosphate lyase 1 (Homo sapiens (Human)) | BDBM65304 (US10166249, Example 622 | US9522888, 622) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description Compounds were loaded in a 384 Falcon v-bottom plate (0.5 l/well in a 11 point, 3-fold dilution). Membranes prepared from S1P1/CHO cells or EDG3-Gal5... | US Patent US10166249 (2019) BindingDB Entry DOI: 10.7270/Q2S75JCM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sphingosine 1-phosphate receptor 3 (Homo sapiens (Human)) | BDBM65304 (US10166249, Example 622 | US9522888, 622) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >625 | n/a | n/a | n/a | 60 |
Bristol-Myers Squibb Company US Patent | Assay Description Compounds were loaded in a 384 Falcon v-bottom plate (0.5 ul/well in a 11 point, 3-fold dilution). Membranes prepared from S1P1/CHO cells or EDG3-Gal... | US Patent US9522888 (2016) BindingDB Entry DOI: 10.7270/Q20K27HV | |||||||||||
More data for this Ligand-Target Pair |