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SMILES: COc1cccc(CC(CS)C(=O)Nc2c[nH]c(c2)C(O)=O)c1

InChI Key: InChIKey=XRMVSIGVJPNKLV-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 85435   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neprilysin


(Rattus norvegicus (Rat))		BDBM85435
PNG
(NEP inhibitor, 6o)
Show SMILES COc1cccc(CC(CS)C(=O)Nc2c[nH]c(c2)C(O)=O)c1
Show InChI InChI=1S/C16H18N2O4S/c1-22-13-4-2-3-10(6-13)5-11(9-23)15(19)18-12-7-14(16(20)21)17-8-12/h2-4,6-8,11,17,23H,5,9H2,1H3,(H,18,19)(H,20,21)
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Article
PubMed
n/an/a 5n/an/an/an/an/a25



R&D, Zambon Group Spa



Assay Description
Enzyme inhibition assay using neutrol endopeptiase EC 3.4.24.11 (NEP).

J Enzym Inhib 12: 155-60 (1997)


Article DOI: 10.3109/14756369709035816
BindingDB Entry DOI: 10.7270/Q2FQ9V4F
More data for this
Ligand-Target Pair