BDBM8833 3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}phenyl)-1-(4-methoxyphenyl)urea::N-[4-(4-Amino-6-methylthieno[2,3-d]pyrimidin-5-yl)-phenyl]-N -(4-methoxyphenyl)urea::Thienopyrimidine deriv. 15
SMILES: COc1ccc(NC(=O)Nc2ccc(cc2)-c2c(C)sc3ncnc(N)c23)cc1
InChI Key: InChIKey=ZPSQSBRNPLBDHP-UHFFFAOYSA-N
Data: 7 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM8833 (3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 69 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories | Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor... | J Med Chem 48: 6066-83 (2005) Article DOI: 10.1021/jm050458h BindingDB Entry DOI: 10.7270/Q2WD3XSF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM8833 (3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories | Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor... | J Med Chem 48: 6066-83 (2005) Article DOI: 10.1021/jm050458h BindingDB Entry DOI: 10.7270/Q2WD3XSF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiopoietin-1 receptor (Homo sapiens (Human)) | BDBM8833 (3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories | Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor... | J Med Chem 48: 6066-83 (2005) Article DOI: 10.1021/jm050458h BindingDB Entry DOI: 10.7270/Q2WD3XSF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM8833 (3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 15.1 | n/a | n/a | n/a | n/a | n/a | n/a |
Dalian University Curated by ChEMBL | Assay Description Inhibition of cKIT | J Mol Graph Model 26: 236-45 (2007) Article DOI: 10.1016/j.jmgm.2006.12.001 BindingDB Entry DOI: 10.7270/Q2GQ7019 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiopoietin-1 receptor (Homo sapiens (Human)) | BDBM8833 (3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.58E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Dalian University Curated by ChEMBL | Assay Description Inhibition of Tie2 | J Mol Graph Model 26: 236-45 (2007) Article DOI: 10.1016/j.jmgm.2006.12.001 BindingDB Entry DOI: 10.7270/Q2GQ7019 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM8833 (3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 69.2 | n/a | n/a | n/a | n/a | n/a | n/a |
Dalian University Curated by ChEMBL | Assay Description Inhibition of KDR | J Mol Graph Model 26: 236-45 (2007) Article DOI: 10.1016/j.jmgm.2006.12.001 BindingDB Entry DOI: 10.7270/Q2GQ7019 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM8833 (3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Punjabi University Curated by ChEMBL | Assay Description Inhibition of c-Kit by HTRF method | Eur J Med Chem 45: 393-404 (2010) Article DOI: 10.1016/j.ejmech.2009.09.013 BindingDB Entry DOI: 10.7270/Q2RX9C6D | |||||||||||
More data for this Ligand-Target Pair |