BDBM8853 3-(4-{4-amino-6-propylthieno[2,3-d]pyrimidin-5-yl}phenyl)-1-(3-methylphenyl)urea::N-[4-(4-Amino-6-propylthieno[2,3-d]pyrimidin-5-yl)-phenyl]-N -(3-methylphenyl)urea::Thienopyrimidine deriv. 79

SMILES: CCCc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1

InChI Key: InChIKey=MKUGRPMZUYUAIX-UHFFFAOYSA-N

Data: 7 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 8853   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM8853 (3-(4-{4-amino-6-propylthieno[2,3-d]pyrimidin-5-yl}...) Show SMILES CCCc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1 Show InChI InChI=1S/C23H23N5OS/c1-3-5-18-19(20-21(24)25-13-26-22(20)30-18)15-8-10-16(11-9-15)27-23(29)28-17-7-4-6-14(2)12-17/h4,6-13H,3,5H2,1-2H3,(H2,24,25,26)(H2,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 48: 6066-83 (2005) Article DOI: 10.1021/jm050458h BindingDB Entry DOI: 10.7270/Q2WD3XSF
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM8853 (3-(4-{4-amino-6-propylthieno[2,3-d]pyrimidin-5-yl}...) Show SMILES CCCc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1 Show InChI InChI=1S/C23H23N5OS/c1-3-5-18-19(20-21(24)25-13-26-22(20)30-18)15-8-10-16(11-9-15)27-23(29)28-17-7-4-6-14(2)12-17/h4,6-13H,3,5H2,1-2H3,(H2,24,25,26)(H2,27,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	82	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 48: 6066-83 (2005) Article DOI: 10.1021/jm050458h BindingDB Entry DOI: 10.7270/Q2WD3XSF
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM8853 (3-(4-{4-amino-6-propylthieno[2,3-d]pyrimidin-5-yl}...) Show SMILES CCCc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1 Show InChI InChI=1S/C23H23N5OS/c1-3-5-18-19(20-21(24)25-13-26-22(20)30-18)15-8-10-16(11-9-15)27-23(29)28-17-7-4-6-14(2)12-17/h4,6-13H,3,5H2,1-2H3,(H2,24,25,26)(H2,27,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 48: 6066-83 (2005) Article DOI: 10.1021/jm050458h BindingDB Entry DOI: 10.7270/Q2WD3XSF
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM8853 (3-(4-{4-amino-6-propylthieno[2,3-d]pyrimidin-5-yl}...) Show SMILES CCCc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1 Show InChI InChI=1S/C23H23N5OS/c1-3-5-18-19(20-21(24)25-13-26-22(20)30-18)15-8-10-16(11-9-15)27-23(29)28-17-7-4-6-14(2)12-17/h4,6-13H,3,5H2,1-2H3,(H2,24,25,26)(H2,27,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	288	n/a	n/a	n/a	n/a	n/a	n/a
Dalian University Curated by ChEMBL					Assay Description Inhibition of Tie2				J Mol Graph Model 26: 236-45 (2007) Article DOI: 10.1016/j.jmgm.2006.12.001 BindingDB Entry DOI: 10.7270/Q2GQ7019
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM8853 (3-(4-{4-amino-6-propylthieno[2,3-d]pyrimidin-5-yl}...) Show SMILES CCCc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1 Show InChI InChI=1S/C23H23N5OS/c1-3-5-18-19(20-21(24)25-13-26-22(20)30-18)15-8-10-16(11-9-15)27-23(29)28-17-7-4-6-14(2)12-17/h4,6-13H,3,5H2,1-2H3,(H2,24,25,26)(H2,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	26.3	n/a	n/a	n/a	n/a	n/a	n/a
Dalian University Curated by ChEMBL					Assay Description Inhibition of KDR				J Mol Graph Model 26: 236-45 (2007) Article DOI: 10.1016/j.jmgm.2006.12.001 BindingDB Entry DOI: 10.7270/Q2GQ7019
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM8853 (3-(4-{4-amino-6-propylthieno[2,3-d]pyrimidin-5-yl}...) Show SMILES CCCc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1 Show InChI InChI=1S/C23H23N5OS/c1-3-5-18-19(20-21(24)25-13-26-22(20)30-18)15-8-10-16(11-9-15)27-23(29)28-17-7-4-6-14(2)12-17/h4,6-13H,3,5H2,1-2H3,(H2,24,25,26)(H2,27,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	81.3	n/a	n/a	n/a	n/a	n/a	n/a
Dalian University Curated by ChEMBL					Assay Description Inhibition of cKIT				J Mol Graph Model 26: 236-45 (2007) Article DOI: 10.1016/j.jmgm.2006.12.001 BindingDB Entry DOI: 10.7270/Q2GQ7019
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM8853 (3-(4-{4-amino-6-propylthieno[2,3-d]pyrimidin-5-yl}...) Show SMILES CCCc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1 Show InChI InChI=1S/C23H23N5OS/c1-3-5-18-19(20-21(24)25-13-26-22(20)30-18)15-8-10-16(11-9-15)27-23(29)28-17-7-4-6-14(2)12-17/h4,6-13H,3,5H2,1-2H3,(H2,24,25,26)(H2,27,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	82	n/a	n/a	n/a	n/a	n/a	n/a
Punjabi University Curated by ChEMBL					Assay Description Inhibition of c-Kit by HTRF method				Eur J Med Chem 45: 393-404 (2010) Article DOI: 10.1016/j.ejmech.2009.09.013 BindingDB Entry DOI: 10.7270/Q2RX9C6D
					More data for this Ligand-Target Pair