BDBM50342278 (2-Ethylbenzofuran-3-yl)(4-hydroxyphenyl)methanone::Benzarone::CHEMBL1474963::US9725430, Compound 1a::US9962362, Compound 1a

SMILES: CCc1oc2ccccc2c1C(=O)c1ccc(O)cc1

InChI Key: InChIKey=RFRXIWQYSOIBDI-UHFFFAOYSA-N

Data: 7 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50342278   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Solute carrier family 22 member 12 (Homo sapiens (Human))	BDBM50342278 ((2-Ethylbenzofuran-3-yl)(4-hydroxyphenyl)methanone...) Show SMILES CCc1oc2ccccc2c1C(=O)c1ccc(O)cc1 Show InChI InChI=1S/C17H14O3/c1-2-14-16(13-5-3-4-6-15(13)20-14)17(19)11-7-9-12(18)10-8-11/h3-10,18H,2H2,1H3	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Anschutz Medical Campus Curated by ChEMBL					Assay Description Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation cou...				J Med Chem 54: 2701-13 (2011) Article DOI: 10.1021/jm1015022 BindingDB Entry DOI: 10.7270/Q2P26ZDR
					More data for this Ligand-Target Pair
Eyes absent homolog 3 (EYA3) (ED) (Homo sapiens (Human))	BDBM50342278 ((2-Ethylbenzofuran-3-yl)(4-hydroxyphenyl)methanone...) Show SMILES CCc1oc2ccccc2c1C(=O)c1ccc(O)cc1 Show InChI InChI=1S/C17H14O3/c1-2-14-16(13-5-3-4-6-15(13)20-14)17(19)11-7-9-12(18)10-8-11/h3-10,18H,2H2,1H3	GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	1.92E+4	n/a	n/a	n/a	n/a	n/a	n/a
CHILDREN HOSPITAL MEDICAL CENTER US Patent					Assay Description An inhibitory assay was conducted using the previously described p-nitrophenylphosphate assay (Rayapureddi, J. P. et al. Nature 426, 295-298 (2003))....				US Patent US9725430 (2017) BindingDB Entry DOI: 10.7270/Q23F4RSZ
					More data for this Ligand-Target Pair
Eyes absent homolog 3 (EYA3) (Homo sapiens (Human))	BDBM50342278 ((2-Ethylbenzofuran-3-yl)(4-hydroxyphenyl)methanone...) Show SMILES CCc1oc2ccccc2c1C(=O)c1ccc(O)cc1 Show InChI InChI=1S/C17H14O3/c1-2-14-16(13-5-3-4-6-15(13)20-14)17(19)11-7-9-12(18)10-8-11/h3-10,18H,2H2,1H3	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
CHILDREN HOSPITAL MEDICAL CENTER US Patent					Assay Description An inhibitory assay was conducted using the previously described p-nitrophenylphosphate assay (Rayapureddi, J. P. et al. Nature 426, 295-298 (2003))....				US Patent US9725430 (2017) BindingDB Entry DOI: 10.7270/Q23F4RSZ
					More data for this Ligand-Target Pair
Protein-tyrosine phosphatase 1B (Homo sapiens (Human))	BDBM50342278 ((2-Ethylbenzofuran-3-yl)(4-hydroxyphenyl)methanone...) Show SMILES CCc1oc2ccccc2c1C(=O)c1ccc(O)cc1 Show InChI InChI=1S/C17H14O3/c1-2-14-16(13-5-3-4-6-15(13)20-14)17(19)11-7-9-12(18)10-8-11/h3-10,18H,2H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description The compounds were then tested using full-length human recombinant, purified EYA3 and pNPP as a substrate. Compounds were dissolved in DMSO and dilut...				Bioorg Med Chem Lett 16: 5488-92 (2006) BindingDB Entry DOI: 10.7270/Q2ZK5JZ7
					More data for this Ligand-Target Pair
EYA3(ED) (Mus musculus (Mouse))	BDBM50342278 ((2-Ethylbenzofuran-3-yl)(4-hydroxyphenyl)methanone...) Show SMILES CCc1oc2ccccc2c1C(=O)c1ccc(O)cc1 Show InChI InChI=1S/C17H14O3/c1-2-14-16(13-5-3-4-6-15(13)20-14)17(19)11-7-9-12(18)10-8-11/h3-10,18H,2H2,1H3	GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	1.92E+4	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description The compounds were then tested using full-length human recombinant, purified EYA3 and pNPP as a substrate. Compounds were dissolved in DMSO and dilut...				Bioorg Med Chem Lett 16: 5488-92 (2006) BindingDB Entry DOI: 10.7270/Q2ZK5JZ7
					More data for this Ligand-Target Pair
Eyes absent homolog 3 (EYA3) (Homo sapiens (Human))	BDBM50342278 ((2-Ethylbenzofuran-3-yl)(4-hydroxyphenyl)methanone...) Show SMILES CCc1oc2ccccc2c1C(=O)c1ccc(O)cc1 Show InChI InChI=1S/C17H14O3/c1-2-14-16(13-5-3-4-6-15(13)20-14)17(19)11-7-9-12(18)10-8-11/h3-10,18H,2H2,1H3	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description The compounds were then tested using full-length human recombinant, purified EYA3 and pNPP as a substrate. Compounds were dissolved in DMSO and dilut...				Bioorg Med Chem Lett 16: 5488-92 (2006) BindingDB Entry DOI: 10.7270/Q2ZK5JZ7
					More data for this Ligand-Target Pair
Protein-tyrosine phosphatase 1B (PTP1B) (Homo sapiens (Human))	BDBM50342278 ((2-Ethylbenzofuran-3-yl)(4-hydroxyphenyl)methanone...) Show SMILES CCc1oc2ccccc2c1C(=O)c1ccc(O)cc1 Show InChI InChI=1S/C17H14O3/c1-2-14-16(13-5-3-4-6-15(13)20-14)17(19)11-7-9-12(18)10-8-11/h3-10,18H,2H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
CHILDREN HOSPITAL MEDICAL CENTER US Patent					Assay Description An inhibitory assay was conducted using the previously described p-nitrophenylphosphate assay (Rayapureddi, J. P. et al. Nature 426, 295-298 (2003))....				US Patent US9725430 (2017) BindingDB Entry DOI: 10.7270/Q23F4RSZ
					More data for this Ligand-Target Pair