BDBM50135167 (+)-epicatechin::(-) epicatechine::(2S,3S)-2-(3,4-Dihydroxy-phenyl)-chroman-3,5,7-triol::CHEMBL129482::Epicatechin
SMILES: O[C@H]1Cc2c(O)cc(O)cc2O[C@H]1c1ccc(O)c(O)c1
InChI Key: InChIKey=PFTAWBLQPZVEMU-ZFWWWQNUSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Prostaglandin G/H synthase (cyclooxygenase) (Ovis aries (Sheep)) | BDBM50135167 ((+)-epicatechin | (-) epicatechine | (2S,3S)-2-(3,...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.28E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pennsylvania School of Medicine Curated by ChEMBL | Assay Description Inhibition of cyclooxygenase activity of COX1 in sheep seminal vesicle in presence of 1 mM phenol by cyclooxygenase assay | J Nat Prod 67: 1777-82 (2004) Article DOI: 10.1021/np0498410 BindingDB Entry DOI: 10.7270/Q2XD12JH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase (cyclooxygenase) (Ovis aries (Sheep)) | BDBM50135167 ((+)-epicatechin | (-) epicatechine | (2S,3S)-2-(3,...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 2.51E+4 | n/a | n/a | n/a | n/a | n/a |
University of Pennsylvania School of Medicine Curated by ChEMBL | Assay Description Binding affinity to COX1 in sheep seminal vesicle | J Nat Prod 67: 1777-82 (2004) Article DOI: 10.1021/np0498410 BindingDB Entry DOI: 10.7270/Q2XD12JH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fatty acid synthase (Homo sapiens (Human)) | BDBM50135167 ((+)-epicatechin | (-) epicatechine | (2S,3S)-2-(3,...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of FAS at 1000 uM | Bioorg Med Chem Lett 20: 6045-7 (2010) Article DOI: 10.1016/j.bmcl.2010.08.061 BindingDB Entry DOI: 10.7270/Q2TT4R6N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM50135167 ((+)-epicatechin | (-) epicatechine | (2S,3S)-2-(3,...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 2.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyungpook National University Curated by ChEMBL | Assay Description Inhibitory activity of the compound against recombinant human Beta-secretase 1 | Bioorg Med Chem Lett 13: 3905-8 (2003) BindingDB Entry DOI: 10.7270/Q28K78HN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuraminidase (Influenza A virus) | BDBM50135167 ((+)-epicatechin | (-) epicatechine | (2S,3S)-2-(3,...) | PDB MMDB B.MOAD GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Peking Union Medical College Curated by ChEMBL | Assay Description Inhibition of Influenza A Jiangsu/10/2003 virus neuraminidase activity by MUN-ANA substrate based fluorimetric assay | Bioorg Med Chem 16: 7141-7 (2008) Article DOI: 10.1016/j.bmc.2008.06.049 BindingDB Entry DOI: 10.7270/Q2R2145D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase (cyclooxygenase) (Ovis aries (Sheep)) | BDBM50135167 ((+)-epicatechin | (-) epicatechine | (2S,3S)-2-(3,...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pennsylvania School of Medicine Curated by ChEMBL | Assay Description Inhibition of peroxidase activity of COX1 in heep seminal vesicle by TMPD assay | J Nat Prod 67: 1777-82 (2004) Article DOI: 10.1021/np0498410 BindingDB Entry DOI: 10.7270/Q2XD12JH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuraminidase (Influenza A virus) | BDBM50135167 ((+)-epicatechin | (-) epicatechine | (2S,3S)-2-(3,...) | PDB MMDB B.MOAD GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Peking Union Medical College Curated by ChEMBL | Assay Description Inhibition of Influenza A Jinan/15/90 H3N2 virus neuraminidase activity by MUN-ANA substrate based fluorimetric assay | Bioorg Med Chem 16: 7141-7 (2008) Article DOI: 10.1016/j.bmc.2008.06.049 BindingDB Entry DOI: 10.7270/Q2R2145D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuraminidase (Influenza A virus) | BDBM50135167 ((+)-epicatechin | (-) epicatechine | (2S,3S)-2-(3,...) | PDB MMDB B.MOAD GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Peking Union Medical College Curated by ChEMBL | Assay Description Inhibition of Influenza A PR/8/34 H1N1 virus neuraminidase activity by MUN-ANA substrate based fluorimetric assay | Bioorg Med Chem 16: 7141-7 (2008) Article DOI: 10.1016/j.bmc.2008.06.049 BindingDB Entry DOI: 10.7270/Q2R2145D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM50135167 ((+)-epicatechin | (-) epicatechine | (2S,3S)-2-(3,...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 2.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyungpook National University Curated by ChEMBL | Assay Description Inhibition of human Beta-secretase 1 | Bioorg Med Chem Lett 13: 3905-8 (2003) BindingDB Entry DOI: 10.7270/Q28K78HN | |||||||||||
More data for this Ligand-Target Pair |