BDBM50080827 (2R,6S)-1-Methyl-2,6-diphenethyl-piperidine::(2S,6R)-1-Methyl-2,6-diphenethyl-piperidine::CHEMBL1085811::CHEMBL333465::Lobelane::cis-N-methyl-2,6-diphenethylpiperidine
SMILES: CN1[C@@H](CCc2ccccc2)CCC[C@H]1CCc1ccccc1
InChI Key: InChIKey=ISVBJSRQEBWKPB-SZPZYZBQSA-N
Data: 23 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Vesicular monoamine transporter 2 (VMAT2) (Rattus norvegicus (Rat)) | BDBM50080827 ((2R,6S)-1-Methyl-2,6-diphenethyl-piperidine | (2S,...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 33 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky Curated by ChEMBL | Assay Description Inhibition of [3H]dopamine uptake at VMAT2 in rat brain synaptic vesicle by liquid scintillation spectroscopy | J Med Chem 52: 7878-82 (2009) Article DOI: 10.1021/jm900770h BindingDB Entry DOI: 10.7270/Q25X29V5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vesicular monoamine transporter 2 (VMAT2) (Rattus norvegicus (Rat)) | BDBM50080827 ((2R,6S)-1-Methyl-2,6-diphenethyl-piperidine | (2S,...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 45 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky Curated by ChEMBL | Assay Description Inhibition of VMAT2-mediated [3H]dopamine uptake in rat synaptic vesicle membranes | Bioorg Med Chem Lett 20: 3584-7 (2010) Article DOI: 10.1016/j.bmcl.2010.04.117 BindingDB Entry DOI: 10.7270/Q2N879Z6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vesicular monoamine transporter 2 (VMAT2) (Rattus norvegicus (Rat)) | BDBM50080827 ((2R,6S)-1-Methyl-2,6-diphenethyl-piperidine | (2S,...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 45 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky Curated by ChEMBL | Assay Description Inhibition of VMAT2-mediated [3H]-dopamine uptake in rat striata isolated synaptic vesicles by liquid scintillation spectroscopy | Bioorg Med Chem 21: 6771-7 (2013) Article DOI: 10.1016/j.bmc.2013.08.001 BindingDB Entry DOI: 10.7270/Q23X883J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Synaptic vesicular amine transporter (Rattus norvegicus (Rat)) | BDBM50080827 ((2R,6S)-1-Methyl-2,6-diphenethyl-piperidine | (2S,...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 45 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky Curated by ChEMBL | Assay Description Inhibition of [3H]dopamine uptake at VMAT2 in rat synaptic vesicles after 8 mins by liquid scintillation spectrometry | Bioorg Med Chem Lett 27: 5467-5472 (2017) Article DOI: 10.1016/j.bmcl.2017.10.039 BindingDB Entry DOI: 10.7270/Q2BP05B5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Synaptic vesicular amine transporter (Rattus norvegicus (Rat)) | BDBM50080827 ((2R,6S)-1-Methyl-2,6-diphenethyl-piperidine | (2S,...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 45 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arkansas for Medical Sciences Curated by ChEMBL | Assay Description Inhibition of [3H]DA uptake at VMAT2 in rat striatal synaptic vesicles | Medchemcomm 4: 564-568 (2013) Article DOI: 10.1039/c3md20374c BindingDB Entry DOI: 10.7270/Q2KD21VD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vesicular monoamine transporter 2 (VMAT2) (Rattus norvegicus (Rat)) | BDBM50080827 ((2R,6S)-1-Methyl-2,6-diphenethyl-piperidine | (2S,...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 45 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky Curated by ChEMBL | Assay Description Inhibition of VMAT2-mediated [3H]DA uptake in rat brain synaptic vesicles by liquid scintillation spectrometry | Bioorg Med Chem Lett 25: 2613-6 (2015) Article DOI: 10.1016/j.bmcl.2015.04.105 BindingDB Entry DOI: 10.7270/Q22V2HV1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vesicular monoamine transporter 2 (VMAT2) (Rattus norvegicus (Rat)) | BDBM50080827 ((2R,6S)-1-Methyl-2,6-diphenethyl-piperidine | (2S,...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 67 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arkansas for Medical Sciences Curated by ChEMBL | Assay Description Inhibition of VMAT2 in rat striatal synaptic vesicle assessed as reduction of [3H]dopamine uptake after 8 mins by liquid scintillation spectrometric ... | Bioorg Med Chem Lett 26: 2422-7 (2016) BindingDB Entry DOI: 10.7270/Q2BC41DT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM50080827 ((2R,6S)-1-Methyl-2,6-diphenethyl-piperidine | (2S,...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 97 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky Curated by PDSP Ki Database | J Pharmacol Exp Ther 310: 1035-45 (2004) Article DOI: 10.1124/jpet.104.068098 BindingDB Entry DOI: 10.7270/Q2WH2NJN | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50080827 ((2R,6S)-1-Methyl-2,6-diphenethyl-piperidine | (2S,...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 530 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky Curated by PDSP Ki Database | J Pharmacol Exp Ther 310: 1035-45 (2004) Article DOI: 10.1124/jpet.104.068098 BindingDB Entry DOI: 10.7270/Q2WH2NJN | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vesicular monoamine transporter 2 (VMAT2) (Rattus norvegicus (Rat)) | BDBM50080827 ((2R,6S)-1-Methyl-2,6-diphenethyl-piperidine | (2S,...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 970 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky Curated by ChEMBL | Assay Description Displacement of [3H]dihydrotetrabenazine from vesicular monoamine transporter-2 in rat brain synaptosome | Bioorg Med Chem Lett 18: 6509-12 (2008) Article DOI: 10.1016/j.bmcl.2008.10.042 BindingDB Entry DOI: 10.7270/Q2NK3DW4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vesicular monoamine transporter 2 (VMAT2) (Rattus norvegicus (Rat)) | BDBM50080827 ((2R,6S)-1-Methyl-2,6-diphenethyl-piperidine | (2S,...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 970 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky Curated by ChEMBL | Assay Description Displacement of [3H]DTBZ from VMAT2 in rat whole brain by liquid scintillation spectrometry | Bioorg Med Chem Lett 25: 2613-6 (2015) Article DOI: 10.1016/j.bmcl.2015.04.105 BindingDB Entry DOI: 10.7270/Q22V2HV1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vesicular monoamine transporter 2 (VMAT2) (Rattus norvegicus (Rat)) | BDBM50080827 ((2R,6S)-1-Methyl-2,6-diphenethyl-piperidine | (2S,...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 970 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky Curated by ChEMBL | Assay Description Inhibition constant against [3H]-dihydrotetrabenazine binding to vesicular monoamine transporter-2 of rat synaptic vesicle membranes | Bioorg Med Chem Lett 15: 4463-6 (2005) Article DOI: 10.1016/j.bmcl.2005.07.032 BindingDB Entry DOI: 10.7270/Q2J38S3H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Synaptic vesicular amine transporter (Rattus norvegicus (Rat)) | BDBM50080827 ((2R,6S)-1-Methyl-2,6-diphenethyl-piperidine | (2S,...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 970 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arkansas for Medical Sciences Curated by ChEMBL | Assay Description Inhibition of [3H]DTBZ binding to VMAT2 in rat synaptic vesicle membranes | Medchemcomm 4: 564-568 (2013) Article DOI: 10.1039/c3md20374c BindingDB Entry DOI: 10.7270/Q2KD21VD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Synaptic vesicular amine transporter (Homo sapiens (Human)) | BDBM50080827 ((2R,6S)-1-Methyl-2,6-diphenethyl-piperidine | (2S,...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 970 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky Curated by ChEMBL | Assay Description Binding affinity to VMAT2 receptor | Bioorg Med Chem 18: 640-9 (2010) Article DOI: 10.1016/j.bmc.2009.12.002 BindingDB Entry DOI: 10.7270/Q2XS5WB2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vesicular monoamine transporter 2 (VMAT2) (Rattus norvegicus (Rat)) | BDBM50080827 ((2R,6S)-1-Methyl-2,6-diphenethyl-piperidine | (2S,...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 970 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky Curated by ChEMBL | Assay Description Displacement of [3H]DTBZ from VMAT2 dihydrotetrabenazine binding site in rat brain synaptic vesicle by scintillation counting | J Med Chem 52: 7878-82 (2009) Article DOI: 10.1021/jm900770h BindingDB Entry DOI: 10.7270/Q25X29V5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vesicular monoamine transporter 2 (VMAT2) (Rattus norvegicus (Rat)) | BDBM50080827 ((2R,6S)-1-Methyl-2,6-diphenethyl-piperidine | (2S,...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 970 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky Curated by ChEMBL | Assay Description Inhibition of 5 nM [3H]DTBZ binding to Vesicular Monoamine Transporter (VAMT2) of rat vesicle membranes | J Med Chem 48: 5551-60 (2005) Article DOI: 10.1021/jm0501228 BindingDB Entry DOI: 10.7270/Q2CN74Q9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vesicular monoamine transporter 2 (VMAT2) (Rattus norvegicus (Rat)) | BDBM50080827 ((2R,6S)-1-Methyl-2,6-diphenethyl-piperidine | (2S,...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 970 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky Curated by ChEMBL | Assay Description Displacement of [3H]DTBZ from VMAT2 in rat synaptic vesicle membranes after 30 mins by liquid scintillation counting | Bioorg Med Chem Lett 20: 3584-7 (2010) Article DOI: 10.1016/j.bmcl.2010.04.117 BindingDB Entry DOI: 10.7270/Q2N879Z6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50080827 ((2R,6S)-1-Methyl-2,6-diphenethyl-piperidine | (2S,...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 1.05E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arkansas for Medical Sciences Curated by ChEMBL | Assay Description Inhibition of DAT in rat striatal synaptosomes assessed as reduction of [3H]dopamine uptake preincubated for 5 mins followed by [3H]dopamine addition... | Bioorg Med Chem Lett 26: 2422-7 (2016) BindingDB Entry DOI: 10.7270/Q2BC41DT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent noradrenaline transporter (Homo sapiens (Human)) | BDBM50080827 ((2R,6S)-1-Methyl-2,6-diphenethyl-piperidine | (2S,...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky Curated by PDSP Ki Database | J Pharmacol Exp Ther 310: 1035-45 (2004) Article DOI: 10.1124/jpet.104.068098 BindingDB Entry DOI: 10.7270/Q2WH2NJN | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vesicular monoamine transporter 2 (VMAT2) (Rattus norvegicus (Rat)) | BDBM50080827 ((2R,6S)-1-Methyl-2,6-diphenethyl-piperidine | (2S,...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky Curated by ChEMBL | Assay Description Inhibition constant against [3H]-methyllycaconitine binding to vesicular monoamine transporter-2 of rat brain membranes | Bioorg Med Chem Lett 15: 4463-6 (2005) Article DOI: 10.1016/j.bmcl.2005.07.032 BindingDB Entry DOI: 10.7270/Q2J38S3H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Rattus norvegicus (rat)) | BDBM50080827 ((2R,6S)-1-Methyl-2,6-diphenethyl-piperidine | (2S,...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arkansas for Medical Sciences Curated by ChEMBL | Assay Description Inhibition of SERT in rat striatal synaptosomes assessed as reduction of [3H]5-HT uptake preincubated for 5 mins followed by [3H]5-HT addition measur... | Bioorg Med Chem Lett 26: 2422-7 (2016) BindingDB Entry DOI: 10.7270/Q2BC41DT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vesicular monoamine transporter 2 (VMAT2) (Rattus norvegicus (Rat)) | BDBM50080827 ((2R,6S)-1-Methyl-2,6-diphenethyl-piperidine | (2S,...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.49E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky Curated by ChEMBL | Assay Description Inhibition constant against [3H]-nicotine binding to vesicular monoamine transporter-2 of rat brain membranes | Bioorg Med Chem Lett 15: 4463-6 (2005) Article DOI: 10.1016/j.bmcl.2005.07.032 BindingDB Entry DOI: 10.7270/Q2J38S3H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor (Rattus norvegicus (Rat)) | BDBM50080827 ((2R,6S)-1-Methyl-2,6-diphenethyl-piperidine | (2S,...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 2.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky Curated by ChEMBL | Assay Description Inhibition of 3 nM [3H]-MLA binding to Nicotinic acetylcholine receptor alpha7 of rat brain membranes | J Med Chem 48: 5551-60 (2005) Article DOI: 10.1021/jm0501228 BindingDB Entry DOI: 10.7270/Q2CN74Q9 | |||||||||||
More data for this Ligand-Target Pair |