BDBM67449 2-(2,4-diketo-1,3-diazaspiro[4.5]decan-3-yl)acetic acid [2-keto-4-(trifluoromethyl)chromen-7-yl] ester::2-(2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)acetic acid [2-oxo-4-(trifluoromethyl)-1-benzopyran-7-yl] ester::MLS001141678::SMR000705589::[2-oxidanylidene-4-(trifluoromethyl)chromen-7-yl] 2-[2,4-bis(oxidanylidene)-1,3-diazaspiro[4.5]decan-3-yl]ethanoate::[2-oxo-4-(trifluoromethyl)chromen-7-yl] 2-(2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)acetate::cid_16281348

SMILES: FC(F)(F)c1cc(=O)oc2cc(OC(=O)CN3C(=O)NC4(CCCCC4)C3=O)ccc12

InChI Key: InChIKey=DDLBKBMVMRXEPM-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 67449   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Human immunodeficiency virus type 1 REV (Human immunodeficiency virus 1)	BDBM67449 (2-(2,4-diketo-1,3-diazaspiro[4.5]decan-3-yl)acetic...) Show SMILES FC(F)(F)c1cc(=O)oc2cc(OC(=O)CN3C(=O)NC4(CCCCC4)C3=O)ccc12 Show InChI InChI=1S/C20H17F3N2O6/c21-20(22,23)13-9-15(26)31-14-8-11(4-5-12(13)14)30-16(27)10-25-17(28)19(24-18(25)29)6-2-1-3-7-19/h4-5,8-9H,1-3,6-7,10H2,(H,24,29)	PDB MMDB Reactome pathway KEGG B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	PCBioAssay	n/a	n/a	6.53E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay					Assay Description Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...				PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q29W0CZG
					More data for this Ligand-Target Pair
Beta lactamase (Pseudomonas aeruginosa)	BDBM67449 (2-(2,4-diketo-1,3-diazaspiro[4.5]decan-3-yl)acetic...) Show SMILES FC(F)(F)c1cc(=O)oc2cc(OC(=O)CN3C(=O)NC4(CCCCC4)C3=O)ccc12 Show InChI InChI=1S/C20H17F3N2O6/c21-20(22,23)13-9-15(26)31-14-8-11(4-5-12(13)14)30-16(27)10-25-17(28)19(24-18(25)29)6-2-1-3-7-19/h4-5,8-9H,1-3,6-7,10H2,(H,24,29)	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	PCBioAssay	n/a	n/a	3.48E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay					Assay Description Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...				PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q2G15ZB8
					More data for this Ligand-Target Pair
Toll-like receptor 9 (Homo sapiens (Human))	BDBM67449 (2-(2,4-diketo-1,3-diazaspiro[4.5]decan-3-yl)acetic...) Show SMILES FC(F)(F)c1cc(=O)oc2cc(OC(=O)CN3C(=O)NC4(CCCCC4)C3=O)ccc12 Show InChI InChI=1S/C20H17F3N2O6/c21-20(22,23)13-9-15(26)31-14-8-11(4-5-12(13)14)30-16(27)10-25-17(28)19(24-18(25)29)6-2-1-3-7-19/h4-5,8-9H,1-3,6-7,10H2,(H,24,29)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	PCBioAssay	n/a	n/a	6.52E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay					Assay Description Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...				PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q2KS6Q2P
					More data for this Ligand-Target Pair
defective in Germ Line Development family member (gld-1) (Caenorhabditis elegans)	BDBM67449 (2-(2,4-diketo-1,3-diazaspiro[4.5]decan-3-yl)acetic...) Show SMILES FC(F)(F)c1cc(=O)oc2cc(OC(=O)CN3C(=O)NC4(CCCCC4)C3=O)ccc12 Show InChI InChI=1S/C20H17F3N2O6/c21-20(22,23)13-9-15(26)31-14-8-11(4-5-12(13)14)30-16(27)10-25-17(28)19(24-18(25)29)6-2-1-3-7-19/h4-5,8-9H,1-3,6-7,10H2,(H,24,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	PCBioAssay	n/a	n/a	4.07E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay					Assay Description Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...				PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2QC01ZW
					More data for this Ligand-Target Pair