BDBM50258439 1-(4-bromobenzyl)indoline-2,3-dione::CHEMBL523685::LOR-NEU-c8f11034-5::VU0119498::cid_3008304
SMILES: Brc1ccc(CN2C(=O)C(=O)c3ccccc23)cc1
InChI Key: InChIKey=DELLOEULSHGYCG-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Muscarinic acetylcholine receptor M1 (RAT) | BDBM50258439 (1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | n/a | n/a | 6.04E+3 | n/a | n/a | n/a | n/a |
Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Curated by PubChem BioAssay | Assay Description Assay Provider: P. Jeffrey Conn Assay Provider Affiliation: Vanderbilt University Muscarinic acetylcholine receptors are family A GPCRs comprised of... | PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2K64GH0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (2019-nCoV) | BDBM50258439 (1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | n/a | n/a | 1.98E+5 | n/a | n/a | n/a | n/a | n/a | n/a | |
Israel Institution of Biological Research | Assay Description Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat 784900) using an Echo 555 acoustic dispenser, and DMSO was back-filled for... | bioRxiv 2021: (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human)) | BDBM50258439 (1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 6.38E+3 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Activation of human muscarinic M3 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracell... | J Med Chem 52: 3445-8 (2009) Article DOI: 10.1021/jm900286j BindingDB Entry DOI: 10.7270/Q23B601Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human)) | BDBM50258439 (1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 4.08E+3 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracell... | J Med Chem 52: 3445-8 (2009) Article DOI: 10.1021/jm900286j BindingDB Entry DOI: 10.7270/Q23B601Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M1 (RAT) | BDBM50258439 (1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 6.10E+3 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Agonist activity at rat muscarinic M1 expressed in CHO cells assessed as stimulation of calcium mobilization | Bioorg Med Chem Lett 20: 558-62 (2010) Article DOI: 10.1016/j.bmcl.2009.11.089 BindingDB Entry DOI: 10.7270/Q2PK0G7M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M2 (RAT) | BDBM50258439 (1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Agonist activity at rat muscarinic M2 expressed in CHO cells assessed as stimulation of calcium mobilization | Bioorg Med Chem Lett 20: 558-62 (2010) Article DOI: 10.1016/j.bmcl.2009.11.089 BindingDB Entry DOI: 10.7270/Q2PK0G7M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human)) | BDBM50258439 (1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 6.40E+3 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Agonist activity at human muscarinic M3 expressed in CHO cells assessed as stimulation of calcium mobilization | Bioorg Med Chem Lett 20: 558-62 (2010) Article DOI: 10.1016/j.bmcl.2009.11.089 BindingDB Entry DOI: 10.7270/Q2PK0G7M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M4 (RAT) | BDBM50258439 (1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Agonist activity at rat muscarinic M4 expressed in CHO cells assessed as stimulation of calcium mobilization | Bioorg Med Chem Lett 20: 558-62 (2010) Article DOI: 10.1016/j.bmcl.2009.11.089 BindingDB Entry DOI: 10.7270/Q2PK0G7M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human)) | BDBM50258439 (1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 4.10E+3 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Agonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilization | Bioorg Med Chem Lett 20: 558-62 (2010) Article DOI: 10.1016/j.bmcl.2009.11.089 BindingDB Entry DOI: 10.7270/Q2PK0G7M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human)) | BDBM50258439 (1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...) | UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 6.10E+3 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Positive allosteric modulation of muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mob... | Bioorg Med Chem Lett 20: 5617-22 (2010) Article DOI: 10.1016/j.bmcl.2010.08.042 BindingDB Entry DOI: 10.7270/Q2CR5TK2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human)) | BDBM50258439 (1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Positive allosteric modulation of muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as effect on acetylcholine-induced intrac... | Bioorg Med Chem Lett 20: 5617-22 (2010) Article DOI: 10.1016/j.bmcl.2010.08.042 BindingDB Entry DOI: 10.7270/Q2CR5TK2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human)) | BDBM50258439 (1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 6.40E+3 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Positive allosteric modulation of muscarinic M3 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mob... | Bioorg Med Chem Lett 20: 5617-22 (2010) Article DOI: 10.1016/j.bmcl.2010.08.042 BindingDB Entry DOI: 10.7270/Q2CR5TK2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human)) | BDBM50258439 (1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Positive allosteric modulation of muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as effect on acetylcholine-induced intrac... | Bioorg Med Chem Lett 20: 5617-22 (2010) Article DOI: 10.1016/j.bmcl.2010.08.042 BindingDB Entry DOI: 10.7270/Q2CR5TK2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human)) | BDBM50258439 (1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mob... | Bioorg Med Chem Lett 20: 5617-22 (2010) Article DOI: 10.1016/j.bmcl.2010.08.042 BindingDB Entry DOI: 10.7270/Q2CR5TK2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human)) | BDBM50258439 (1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 4.10E+3 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Positive allosteric modulation activity at muscarinic M5 receptor | J Med Chem 55: 1445-64 (2012) Article DOI: 10.1021/jm201139r BindingDB Entry DOI: 10.7270/Q25D8SWH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human)) | BDBM50258439 (1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...) | UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Positive allosteric modulation activity at muscarinic M1 receptor | J Med Chem 55: 1445-64 (2012) Article DOI: 10.1021/jm201139r BindingDB Entry DOI: 10.7270/Q25D8SWH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human)) | BDBM50258439 (1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 6.40E+3 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Positive allosteric modulation activity at muscarinic M3 receptor | J Med Chem 55: 1445-64 (2012) Article DOI: 10.1021/jm201139r BindingDB Entry DOI: 10.7270/Q25D8SWH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (2019-nCoV) | BDBM50258439 (1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | n/a | n/a | 747 | n/a | n/a | n/a | n/a | n/a | n/a | |
Israel Institution of Biological Research | Assay Description The assay was performed according to the published procedure. Briefly, compounds were seeded into assay-ready plates (Greiner 384PP, cat# 781280) usi... | bioRxiv 2021: (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M1 (RAT) | BDBM50258439 (1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 6.04E+3 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Activation of rat muscarinic M1 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellul... | J Med Chem 52: 3445-8 (2009) Article DOI: 10.1021/jm900286j BindingDB Entry DOI: 10.7270/Q23B601Q | |||||||||||
More data for this Ligand-Target Pair |