BDBM50045698 1-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid::CHEMBL8179::WIN-57294

SMILES: Cc1cc(cc(C)n1)-c1c(F)cc2c(c1F)n(cc(C(O)=O)c2=O)C1CC1

InChI Key: InChIKey=WHXJSJBKDGZVDA-UHFFFAOYSA-N

Data: 6 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50045698   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA topoisomerase II (Homo sapiens (Human))	BDBM50045698 (1-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-di...) Show SMILES Cc1cc(cc(C)n1)-c1c(F)cc2c(c1F)n(cc(C(O)=O)c2=O)C1CC1 Show InChI InChI=1S/C20H16F2N2O3/c1-9-5-11(6-10(2)23-9)16-15(21)7-13-18(17(16)22)24(12-3-4-12)8-14(19(13)25)20(26)27/h5-8,12H,3-4H2,1-2H3,(H,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	n/a	n/a	>5.40E+4	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of calf thymus DNA/ethidium bromide complex formation.				Bioorg Med Chem Lett 5: 405-410 (1995) Article DOI: 10.1016/0960-894X(95)00044-T BindingDB Entry DOI: 10.7270/Q2CZ37N7
					More data for this Ligand-Target Pair
DNA topoisomerase II (Homo sapiens (Human))	BDBM50045698 (1-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-di...) Show SMILES Cc1cc(cc(C)n1)-c1c(F)cc2c(c1F)n(cc(C(O)=O)c2=O)C1CC1 Show InChI InChI=1S/C20H16F2N2O3/c1-9-5-11(6-10(2)23-9)16-15(21)7-13-18(17(16)22)24(12-3-4-12)8-14(19(13)25)20(26)27/h5-8,12H,3-4H2,1-2H3,(H,26,27)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars		n/a	n/a	n/a	n/a	7.60E+3	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitory activity against HeLa cell Topoisomerase II				Citation and Details BindingDB Entry DOI: 10.7270/Q2TX3HJW
					More data for this Ligand-Target Pair
DNA topoisomerase II (Homo sapiens (Human))	BDBM50045698 (1-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-di...) Show SMILES Cc1cc(cc(C)n1)-c1c(F)cc2c(c1F)n(cc(C(O)=O)c2=O)C1CC1 Show InChI InChI=1S/C20H16F2N2O3/c1-9-5-11(6-10(2)23-9)16-15(21)7-13-18(17(16)22)24(12-3-4-12)8-14(19(13)25)20(26)27/h5-8,12H,3-4H2,1-2H3,(H,26,27)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	7.60E+3	n/a	n/a	n/a	n/a
Dainippon Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity in a DNA cleavage assay using HeLa DNA topoisomerase II yielding its effective concentration				J Med Chem 45: 5564-75 (2002) Article DOI: 10.1021/jm010057b BindingDB Entry DOI: 10.7270/Q2XS5Z46
					More data for this Ligand-Target Pair
DNA topoisomerase II (Homo sapiens (Human))	BDBM50045698 (1-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-di...) Show SMILES Cc1cc(cc(C)n1)-c1c(F)cc2c(c1F)n(cc(C(O)=O)c2=O)C1CC1 Show InChI InChI=1S/C20H16F2N2O3/c1-9-5-11(6-10(2)23-9)16-15(21)7-13-18(17(16)22)24(12-3-4-12)8-14(19(13)25)20(26)27/h5-8,12H,3-4H2,1-2H3,(H,26,27)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	n/a	n/a	7.60E+3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for topoisomerase II inhibition in purified HeLa cells by SDS/K+ precipitation method				Bioorg Med Chem Lett 5: 405-410 (1995) Article DOI: 10.1016/0960-894X(95)00044-T BindingDB Entry DOI: 10.7270/Q2CZ37N7
					More data for this Ligand-Target Pair
DNA topoisomerase II (Homo sapiens (Human))	BDBM50045698 (1-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-di...) Show SMILES Cc1cc(cc(C)n1)-c1c(F)cc2c(c1F)n(cc(C(O)=O)c2=O)C1CC1 Show InChI InChI=1S/C20H16F2N2O3/c1-9-5-11(6-10(2)23-9)16-15(21)7-13-18(17(16)22)24(12-3-4-12)8-14(19(13)25)20(26)27/h5-8,12H,3-4H2,1-2H3,(H,26,27)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	7.60E+3	n/a	n/a	n/a	n/a
Sterling Winthrop Pharmaceuticals Research Division Curated by ChEMBL					Assay Description Tested for inhibition of topoisomerase II isolated from HeLa cells by DNA-cleavage assay				J Med Chem 36: 2801-9 (1993) Article DOI: 10.1021/jm00071a010 BindingDB Entry DOI: 10.7270/Q2NK3H89
					More data for this Ligand-Target Pair
DNA topoisomerase II (Homo sapiens (Human))	BDBM50045698 (1-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-di...) Show SMILES Cc1cc(cc(C)n1)-c1c(F)cc2c(c1F)n(cc(C(O)=O)c2=O)C1CC1 Show InChI InChI=1S/C20H16F2N2O3/c1-9-5-11(6-10(2)23-9)16-15(21)7-13-18(17(16)22)24(12-3-4-12)8-14(19(13)25)20(26)27/h5-8,12H,3-4H2,1-2H3,(H,26,27)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars		n/a	n/a	n/a	n/a	7.60E+3	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitory activity in a cell-free assay of DNA cleavage mediated by purified HeLa cell topoisomerase II.				Citation and Details BindingDB Entry DOI: 10.7270/Q2R49SXV
					More data for this Ligand-Target Pair