Found 54 hits for monomerid = 27507 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB
KEGG
UniProtKB/SwissProt
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Similars
| Article PubMed
| 8.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co.
Curated by ChEMBL
| Assay Description Inhibition of human soluble tissue factor/factor VIIa expressed in Origami B (DE3) using D-Ile-Pro-Arg-pNA as substrate after 30 mins by spectrophoto... |
J Med Chem 58: 2799-808 (2015)
Article DOI: 10.1021/jm501982k BindingDB Entry DOI: 10.7270/Q28D007C |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacylase sirtuin-5, mitochondrial
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB
UniProtKB/SwissProt
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Patents
Similars
| Article PubMed
| n/a | n/a | 2.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant SIRT5 assessed as inhibition of substrate desuccinylation using Fluor de Lys-Succinyl green peptide as substrate in p... |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116328 BindingDB Entry DOI: 10.7270/Q23F4TGR |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacylase sirtuin-6
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB
UniProtKB/SwissProt
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Patents
Similars
| PDB Article PubMed
| n/a | n/a | 1.89E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University at Albany
| Assay Description Inhibitory constants (Ki) and IC50 values were determined under saturating substrate conditions by using a fluorimetric assay (components were purcha... |
Chembiochem 18: 931-940 (2017)
Article DOI: 10.1002/cbic.201600655 BindingDB Entry DOI: 10.7270/Q2CJ8CC2 |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB MMDB
NCI pathway KEGG
UniProtKB/SwissProt
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Similars
| PDB Article PubMed
| n/a | n/a | 1.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota
Curated by ChEMBL
| Assay Description Inhibition of full length human SIRT2 expressed in Escherichia coli BL21 (DE3) cells using fluorogenic 7-amino-4-methylcoumarin (AMC)-labeled peptide... |
J Med Chem 57: 8340-57 (2014)
Article DOI: 10.1021/jm500777s BindingDB Entry DOI: 10.7270/Q2KK9DDH |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Similars
| Article PubMed
| n/a | n/a | 7.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota
Curated by ChEMBL
| Assay Description Inhibition of full length human SIRT1 expressed in Escherichia coli BL21 (DE3) cells using fluorogenic 7-amino-4-methylcoumarin (AMC)-labeled peptide... |
J Med Chem 57: 8340-57 (2014)
Article DOI: 10.1021/jm500777s BindingDB Entry DOI: 10.7270/Q2KK9DDH |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB
UniProtKB/SwissProt
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Similars
| Article PubMed
| n/a | n/a | 6.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota
Curated by ChEMBL
| Assay Description Inhibition of catalytically active human SIRT3 (102 to 399 amino acids) expressed in Escherichia coli BL21 (DE3) cells using fluorogenic 7-amino-4-me... |
J Med Chem 57: 8340-57 (2014)
Article DOI: 10.1021/jm500777s BindingDB Entry DOI: 10.7270/Q2KK9DDH |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB MMDB
NCI pathway KEGG
UniProtKB/SwissProt
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Similars
| PDB Article PubMed
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Tokyo
Curated by ChEMBL
| Assay Description Inhibition of human recombinant SIRT2 |
Bioorg Med Chem 23: 328-39 (2015)
Article DOI: 10.1016/j.bmc.2014.11.027 BindingDB Entry DOI: 10.7270/Q2736SJS |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB MMDB
NCI pathway KEGG
UniProtKB/SwissProt
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Similars
| PDB Article PubMed
| n/a | n/a | 1.01E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kuopio
Curated by ChEMBL
| Assay Description Inhibition of human recombinant GST-tagged SIRT2 by histone deacetylase assay |
J Med Chem 47: 6292-8 (2004)
Article DOI: 10.1021/jm049933m BindingDB Entry DOI: 10.7270/Q2S1820Z |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
NAD-dependent protein deacylase sirtuin-5, mitochondrial
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Guiyang Medical University
Curated by ChEMBL
| Assay Description Inhibition of human SIRT5 assessed as reduction in desuccinylase activity using KQTAR(SuK)STGGKA substrate |
Bioorg Med Chem Lett 25: 1671-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.03.018 BindingDB Entry DOI: 10.7270/Q2MK6FKB |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Patents
Similars
| Article PubMed
| n/a | n/a | 1.49E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
National University of Singapore
Curated by ChEMBL
| Assay Description Inhibition of human recombinant SIRT1 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l... |
Eur J Med Chem 92: 145-55 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.027 BindingDB Entry DOI: 10.7270/Q270834V |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB MMDB
NCI pathway KEGG
UniProtKB/SwissProt
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Similars
| PDB Article PubMed
| n/a | n/a | 6.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National University of Singapore
Curated by ChEMBL
| Assay Description Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l... |
Eur J Med Chem 92: 145-55 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.027 BindingDB Entry DOI: 10.7270/Q270834V |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
NAD-dependent protein deacylase sirtuin-6
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB
UniProtKB/SwissProt
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Patents
Similars
| PDB Article PubMed
| n/a | n/a | 1.84E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Guiyang Medical University
Curated by ChEMBL
| Assay Description Inhibition of SIRT6 (unknown origin) using AMC containing peptide substructure by fluorogenic assay |
Eur J Med Chem 96: 245-9 (2015)
Article DOI: 10.1016/j.ejmech.2015.04.008 BindingDB Entry DOI: 10.7270/Q2FT8NRP |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
NAD-dependent protein deacylase sirtuin-6
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB
UniProtKB/SwissProt
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Patents
Similars
| PDB Article PubMed
| n/a | n/a | 2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Guiyang Medical University
Curated by ChEMBL
| Assay Description Inhibition of SIRT6 (unknown origin) using (DABCYL)ISGASE(MyK)DIVHSE(EDANS)G substrate in presence of NAD followed by 1 hr incubation with trypsin by... |
Eur J Med Chem 96: 245-9 (2015)
Article DOI: 10.1016/j.ejmech.2015.04.008 BindingDB Entry DOI: 10.7270/Q2FT8NRP |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB MMDB
UniProtKB/SwissProt
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Patents
Similars
| Article PubMed
| n/a | n/a | 2.10E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description Inhibition of PARP1 (unknown origin) |
Bioorg Med Chem Lett 25: 2340-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.013 BindingDB Entry DOI: 10.7270/Q2N58P2F |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Patents
Similars
| Article PubMed
| n/a | n/a | 5.20E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Akron
Curated by ChEMBL
| Assay Description Inhibition of human SIRT1 |
Bioorg Med Chem Lett 16: 3651-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.04.075 BindingDB Entry DOI: 10.7270/Q2WH2PMZ |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB MMDB
NCI pathway KEGG
UniProtKB/SwissProt
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Similars
| PDB Article PubMed
| n/a | n/a | 3.23E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Albert-Ludwigs-Universität Freiburg
Curated by ChEMBL
| Assay Description Inhibition of human recombinant SIRT2 |
J Med Chem 49: 7307-16 (2006)
Article DOI: 10.1021/jm060118b BindingDB Entry DOI: 10.7270/Q2TQ616P |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB MMDB
UniProtKB/SwissProt
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Patents
Similars
| Article PubMed
| n/a | n/a | 2.10E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of PARP1 (unknown origin) |
Bioorg Med Chem Lett 25: 4557-61 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.060 BindingDB Entry DOI: 10.7270/Q2KD20Q6 |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Patents
Similars
| Article PubMed
| n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Albert-Ludwigs-University Freiburg
Curated by ChEMBL
| Assay Description Inhibition of human SIRT1 using MPSDKTIGG as substrate by liquid scintillation counting analysis in presence of [3H]-acetic acid |
J Med Chem 59: 1599-612 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01517 BindingDB Entry DOI: 10.7270/Q2HX1FH2 |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB MMDB
NCI pathway KEGG
UniProtKB/SwissProt
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Patents
Similars
| PDB Article PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Albert-Ludwigs-University Freiburg
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged recombinant human SIRT2 using MPSDKTIGG as substrate by liquid scintillation counting analysis in presence of [3H]-acetic ac... |
J Med Chem 59: 1599-612 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01517 BindingDB Entry DOI: 10.7270/Q2HX1FH2 |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Patents
Similars
| Article PubMed
| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Nagoya City University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant SIRT1 after 60 mins by fluorimetric analysis |
Bioorg Med Chem Lett 19: 5670-2 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.028 BindingDB Entry DOI: 10.7270/Q2WH2Q1R |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB MMDB
NCI pathway KEGG
UniProtKB/SwissProt
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Patents
Similars
| PDB Article PubMed
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Nagoya City University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant SIRT2 after 60 mins by fluorimetric analysis |
Bioorg Med Chem Lett 19: 5670-2 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.028 BindingDB Entry DOI: 10.7270/Q2WH2Q1R |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB
UniProtKB/SwissProt
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| n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Nagoya City University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant SIRT3 after 60 mins by fluorimetric analysis |
Bioorg Med Chem Lett 19: 5670-2 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.028 BindingDB Entry DOI: 10.7270/Q2WH2Q1R |
More data for this Ligand-Target Pair | |
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB MMDB
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| Article PubMed
| n/a | n/a | 2.10E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johns Hopkins University Brain Science Institute
Curated by ChEMBL
| Assay Description Inhibition of PARP1 |
J Med Chem 53: 4561-84 (2010)
Article DOI: 10.1021/jm100012m BindingDB Entry DOI: 10.7270/Q2NV9JF0 |
More data for this Ligand-Target Pair | |
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB MMDB
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| Article PubMed
| n/a | n/a | 2.10E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Guilford Pharmaceuticals Inc
Curated by ChEMBL
| Assay Description Inhibitory activity against Poly (ADP-ribose) polymerase 1 |
J Med Chem 46: 3138-51 (2003)
Article DOI: 10.1021/jm030109s BindingDB Entry DOI: 10.7270/Q2Z89D5P |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB
NCI pathway Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | <5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
| Assay Description Non-competitive inhibition of recombinant human SIRT1 using acetylated histone as substrate measured after 30 mins by fluorimetric analysis |
Eur J Med Chem 119: 45-69 (2016)
Article DOI: 10.1016/j.ejmech.2016.04.063 BindingDB Entry DOI: 10.7270/Q2VH5QTW |
More data for this Ligand-Target Pair | |
NAD-dependent histone deacetylase SIR2
(Saccharomyces cerevisiae) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB MMDB
Reactome pathway KEGG
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| n/a | n/a | <5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Guru Jambheshwar University of Science and Technology
Curated by ChEMBL
| Assay Description Non-competitive inhibition of recombinant yeast glutathione-S-transferase-tagged SIRT2 using acetylated histone as substrate measured after 30 mins b... |
Eur J Med Chem 119: 45-69 (2016)
Article DOI: 10.1016/j.ejmech.2016.04.063 BindingDB Entry DOI: 10.7270/Q2VH5QTW |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB MMDB
NCI pathway KEGG
UniProtKB/SwissProt
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| n/a | n/a | 3.23E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Albert-Ludwigs-Universit£t Freiburg
Curated by ChEMBL
| Assay Description Inhibition of human recombinant Sirt2 expressed in Escherichia coli BL21 by fluorescent deacetylase assay |
J Med Chem 51: 1203-13 (2008)
Article DOI: 10.1021/jm700972e BindingDB Entry DOI: 10.7270/Q22N534Q |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB MMDB
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| Article PubMed
| n/a | n/a | 2.10E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of PARP1 (unknown origin) |
Bioorg Med Chem Lett 23: 1993-6 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.032 BindingDB Entry DOI: 10.7270/Q2736S9N |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase
(Leishmania infantum) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB
KEGG
UniProtKB/TrEMBL
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| Article PubMed
| n/a | n/a | 3.94E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangsu University
Curated by ChEMBL
| Assay Description Inhibition of Leishmania infantum SIR2RP1 |
Eur J Med Chem 59: 132-40 (2013)
Article DOI: 10.1016/j.ejmech.2012.11.014 BindingDB Entry DOI: 10.7270/Q2CF9RDD |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB
NCI pathway Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 9.04E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of N-terminal His6-tagged SIRT1 coding region (156-664) (unknown origin) expressed in Escherichia coli BL21(DE3) using 31.25 uM ac-RHKKac-... |
Eur J Med Chem 60: 441-50 (2013)
Article DOI: 10.1016/j.ejmech.2012.12.026 BindingDB Entry DOI: 10.7270/Q2WW7K0B |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| n/a | n/a | 2.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of human full length SIRT1 expressed in DE3 cells by fluorimetric assay |
Bioorg Med Chem 17: 7031-41 (2009)
Article DOI: 10.1016/j.bmc.2009.07.073 BindingDB Entry DOI: 10.7270/Q21V5FWG |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase HST2
(Saccharomyces cerevisiae) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB MMDB
KEGG
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| PDB Article PubMed
| n/a | n/a | 9.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of yeast Hst2 by fluorimetric assay |
Bioorg Med Chem 17: 7031-41 (2009)
Article DOI: 10.1016/j.bmc.2009.07.073 BindingDB Entry DOI: 10.7270/Q21V5FWG |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB
NCI pathway Reactome pathway KEGG
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| n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of recombinant SIRT1 using ZMAL substrate after 4 hrs by homogeneous fluorescence assay |
ACS Med Chem Lett 3: 1050-1053 (2012)
Article DOI: 10.1021/ml3002709 BindingDB Entry DOI: 10.7270/Q29C6ZKP |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB MMDB
NCI pathway KEGG
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| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of recombinant SIRT2 using ZMAL substrate after 4 hrs by homogeneous fluorescence assay |
ACS Med Chem Lett 3: 1050-1053 (2012)
Article DOI: 10.1021/ml3002709 BindingDB Entry DOI: 10.7270/Q29C6ZKP |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
NAD-dependent protein deacylase sirtuin-5, mitochondrial
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB
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| Article PubMed
| n/a | n/a | 4.66E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of SIRT5 using ZK(suc)A substrate after 1 hr by homogeneous fluorescence assay |
ACS Med Chem Lett 3: 1050-1053 (2012)
Article DOI: 10.1021/ml3002709 BindingDB Entry DOI: 10.7270/Q29C6ZKP |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB
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| Article PubMed
| n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of recombinant SIRT3 using ZMAL substrate after 4 hrs by homogeneous fluorescence assay |
ACS Med Chem Lett 3: 1050-1053 (2012)
Article DOI: 10.1021/ml3002709 BindingDB Entry DOI: 10.7270/Q29C6ZKP |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB
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| Article PubMed
| n/a | n/a | 3.77E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi del Piemonte Orientale A. Avogadro
Curated by ChEMBL
| Assay Description Inhibition of human SIRT3 expressed in Escherichia coli using Z-MAL as substrate after 6 hrs by fluorescence assay |
Eur J Med Chem 55: 58-66 (2012)
Article DOI: 10.1016/j.ejmech.2012.07.001 BindingDB Entry DOI: 10.7270/Q20K29NG |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 8.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dipartimento di Chimica e Tecnologie del Farmaco "Sapienza" Universit£ di Roma
Curated by ChEMBL
| Assay Description Inhibition of human SIRT1 |
J Med Chem 60: 4780-4804 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01595 BindingDB Entry DOI: 10.7270/Q2JD50D0 |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase
(Leishmania infantum) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB
KEGG
UniProtKB/TrEMBL
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Patents
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| Article PubMed
| n/a | n/a | 4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dipartimento di Chimica e Tecnologie del Farmaco "Sapienza" Universit£ di Roma
Curated by ChEMBL
| Assay Description Inhibition of N-terminal His6-tagged recombinant Leishmania infantum SIR2RP1 expressed in Escherichia coli in presence of NAD+ by fluorimetric method |
J Med Chem 60: 4780-4804 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01595 BindingDB Entry DOI: 10.7270/Q2JD50D0 |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Patents
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| Article PubMed
| n/a | n/a | 1.18E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Dipartimento di Chimica e Tecnologie del Farmaco "Sapienza" Universit£ di Roma
Curated by ChEMBL
| Assay Description Inhibition of human SIRT1 in presence of NAD+ by fluorimetric method |
J Med Chem 60: 4780-4804 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01595 BindingDB Entry DOI: 10.7270/Q2JD50D0 |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase
(Schistosoma mansoni) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/TrEMBL
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| Article PubMed
| n/a | n/a | 2.31E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Freiburg
Curated by ChEMBL
| Assay Description Inhibition of recombinant Schistosoma mansoni sirtuin 2 (21 to 322 residues) expressed in Escherichia coli BL21(DE3) cells assessed as inhibition of ... |
J Med Chem 62: 8733-8759 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00638 BindingDB Entry DOI: 10.7270/Q25142HK |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB MMDB
NCI pathway KEGG
UniProtKB/SwissProt
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| PDB Article PubMed
| n/a | n/a | 4.98E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Freiburg
Curated by ChEMBL
| Assay Description Inhibition of human sirtuin 2 assessed as inhibition of substrate deacetylation using ZMAL as substrate |
J Med Chem 62: 8733-8759 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00638 BindingDB Entry DOI: 10.7270/Q25142HK |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB MMDB
NCI pathway KEGG
UniProtKB/SwissProt
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| PDB Article PubMed
| n/a | n/a | 3.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Nagoya City University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human SIRT2 deacylation activity using Fluor de Lys Sirt2 as substrate measured at 5 mins interval for 30 mins in presence ... |
J Med Chem 62: 5434-5452 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00315 BindingDB Entry DOI: 10.7270/Q2HH6P91 |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Nagoya City University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human C-terminal His6-tagged SIRT1 (Met1 to Ser747 residues) defatty-acylase activity expressed in Escherichia coli using S... |
J Med Chem 62: 5434-5452 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00315 BindingDB Entry DOI: 10.7270/Q2HH6P91 |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Nagoya City University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human SIRT3 (118 to 399 residues) defatty-acylase activity expressed in Escherichia coli using SFP3 as substrate measured a... |
J Med Chem 62: 5434-5452 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00315 BindingDB Entry DOI: 10.7270/Q2HH6P91 |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB MMDB
NCI pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Nagoya City University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human SIRT2 defatty-acylase activity using SFP3 as substrate measured at 5 mins interval for 60 mins in presence of NAD+ by... |
J Med Chem 62: 5434-5452 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00315 BindingDB Entry DOI: 10.7270/Q2HH6P91 |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
NAD-dependent protein deacylase sirtuin-6
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 1.20E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Nagoya City University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human N-terminal polyhis-tagged SIRT6 (1 to 355 residues) defatty-acylase activity expressed in Escherichia coli using SFP3... |
J Med Chem 62: 5434-5452 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00315 BindingDB Entry DOI: 10.7270/Q2HH6P91 |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB MMDB
NCI pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Nagoya City University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human SIRT2 demyristoylase activity using p53(Myr)-AMC as substrate measured after 3 hrs in presence of NAD+ and trypsin by... |
J Med Chem 62: 5434-5452 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00315 BindingDB Entry DOI: 10.7270/Q2HH6P91 |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
NAD-dependent protein deacetylase
(Schistosoma mansoni) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.20E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Freiburg
Curated by ChEMBL
| Assay Description Inhibition of recombinant Schistosoma mansoni sirtuin 2 (21 to 322 residues) expressed in Escherichia coli BL21(DE3) cells assessed as inhibition of ... |
J Med Chem 62: 8733-8759 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00638 BindingDB Entry DOI: 10.7270/Q25142HK |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
(Homo sapiens (Human)) | BDBM27507
![PNG](/data/jpeg/tenK2/BindingDB_27507.png) (3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)Show InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 7.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of human SIRT3 assessed as reduction in deacetylase activity using acetylated H3K9 as substrate preincubated for 15 mins followed by subst... |
J Med Chem 62: 4131-4141 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00191 BindingDB Entry DOI: 10.7270/Q21C21BC |
More data for this Ligand-Target Pair | |