BindingDB PrimarySearch

BDBM100349 US10533001, Example Table 9a.2::US8501944, 371::US9868729, Example 207

SMILES: CNC(=O)[C@H]1CCCN(C1)c1ccc(Nc2ncc(C(N)=O)c(NC3CC3)n2)cc1

InChI Key: InChIKey=CQNHZTVKOGLVDJ-ZDUSSCGKSA-N

Data: 2 IC50 6 Kd

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 100349
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM100349 (US10533001, Example Table 9a.2 \| US8501944, 371 \| ...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a
Portola Pharmaceuticals, Inc. US Patent					Assay Description ATP-site dependent competition binding assay using Ambit KinomeScan Screening kit.				US Patent US8501944 (2013) BindingDB Entry DOI: 10.7270/Q20Z71W0
Portola Pharmaceuticals, Inc. US Patent					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM100349 (US10533001, Example Table 9a.2 \| US8501944, 371 \| ...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a
Portola Pharmaceuticals, Inc. US Patent					Assay Description ATP-site dependent competition binding assay using Ambit KinomeScan Screening kit.				US Patent US8501944 (2013) BindingDB Entry DOI: 10.7270/Q20Z71W0
Portola Pharmaceuticals, Inc. US Patent					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM100349 (US10533001, Example Table 9a.2 \| US8501944, 371 \| ...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a
Portola Pharmaceuticals, Inc. US Patent					Assay Description This assay is an ATP-site dependent competition binding assay in which human kinases of interest are fused to a proprietary tag (T7 bacteriophage). T...				US Patent US8937070 (2015) BindingDB Entry DOI: 10.7270/Q2GB22RV
Portola Pharmaceuticals, Inc. US Patent					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM100349 (US10533001, Example Table 9a.2 \| US8501944, 371 \| ...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a
PORTOLA PHARMACEUTICALS, INC. US Patent					Assay Description Syk and JAK: The activity of a specified compound as an inhibitor of a JAK kinase may be assessed in vitro or in vivo. In some embodiments, the activ...				US Patent US10533001 (2020) BindingDB Entry DOI: 10.7270/Q2Z03BJR
PORTOLA PHARMACEUTICALS, INC. US Patent					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM100349 (US10533001, Example Table 9a.2 \| US8501944, 371 \| ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description SYK tyrosine phosphorylation activity is measured using the LANCE� Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....				J Med Chem 50: 3528-39 (2007) BindingDB Entry DOI: 10.7270/Q28K7CDJ
Amgen					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM100349 (US10533001, Example Table 9a.2 \| US8501944, 371 \| ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
PORTOLA PHARMACEUTICALS, INC. US Patent					Assay Description Syk and JAK: The activity of a specified compound as an inhibitor of a JAK kinase may be assessed in vitro or in vivo. In some embodiments, the activ...				US Patent US10533001 (2020) BindingDB Entry DOI: 10.7270/Q2Z03BJR
PORTOLA PHARMACEUTICALS, INC. US Patent					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM100349 (US10533001, Example Table 9a.2 \| US8501944, 371 \| ...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a
PORTOLA PHARMACEUTICALS, INC. US Patent					Assay Description Syk and JAK: The activity of a specified compound as an inhibitor of a JAK kinase may be assessed in vitro or in vivo. In some embodiments, the activ...				US Patent US10533001 (2020) BindingDB Entry DOI: 10.7270/Q2Z03BJR
PORTOLA PHARMACEUTICALS, INC. US Patent					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM100349 (US10533001, Example Table 9a.2 \| US8501944, 371 \| ...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a
Portola Pharmaceuticals, Inc. US Patent					Assay Description This assay is an ATP-site dependent competition binding assay in which human kinases of interest are fused to a proprietary tag (T7 bacteriophage). T...				US Patent US8937070 (2015) BindingDB Entry DOI: 10.7270/Q2GB22RV
Portola Pharmaceuticals, Inc. US Patent					More data for this Ligand-Target Pair