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BDBM101684 US8530504, 46

SMILES: CCCN(C1CCOC1)c1c(OC)nn2c(csc12)-c1c(OC)cc(COCC)cc1OC

InChI Key: InChIKey=AEPDUIFAQHQJHH-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 101684   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM101684
PNG
(US8530504, 46)
Show SMILES CCCN(C1CCOC1)c1c(OC)nn2c(csc12)-c1c(OC)cc(COCC)cc1OC |(-6.53,3.14,;-5.04,2.74,;-3.95,3.83,;-2.46,3.43,;-1.37,4.52,;-1.85,5.99,;-.6,6.89,;.64,5.99,;.17,4.52,;-2.06,1.95,;-2.97,.7,;-4.51,.7,;-5.28,-.63,;-2.06,-.54,;-.6,-.07,;.87,-.54,;1.77,.7,;.87,1.95,;-.6,1.47,;1.27,-2.03,;2.75,-2.43,;3.84,-1.34,;5.33,-1.74,;3.15,-3.92,;2.06,-5.01,;2.46,-6.49,;3.95,-6.89,;5.04,-5.8,;6.53,-6.2,;.57,-4.61,;.18,-3.12,;-1.31,-2.72,;-2.4,-3.81,)|
Show InChI InChI=1S/C24H33N3O5S/c1-6-9-26(17-8-10-32-14-17)22-23(30-5)25-27-18(15-33-24(22)27)21-19(28-3)11-16(13-31-7-2)12-20(21)29-4/h11-12,15,17H,6-10,13-14H2,1-5H3
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Similars
US Patent
n/an/a 26n/an/an/an/an/an/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
A binding competition experiment with CRF was conducted by the SPA (GE Healthcare) method using a 96-well plate.

US Patent US8530504 (2013)


BindingDB Entry DOI: 10.7270/Q29885NS
More data for this
Ligand-Target Pair