BDBM102495 US8536165, 100

SMILES: OC(=O)c1cc(ccc1Nc1cnc(nc1)-c1cc(F)ccc1F)C1CC1

InChI Key: InChIKey=BXJHMCWUEMJXJP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 102495   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dihydroorotate dehydrogenase (Homo sapiens (Human))	BDBM102495 (US8536165, 100) Show SMILES OC(=O)c1cc(ccc1Nc1cnc(nc1)-c1cc(F)ccc1F)C1CC1 Show InChI InChI=1S/C20H15F2N3O2/c21-13-4-5-17(22)15(8-13)19-23-9-14(10-24-19)25-18-6-3-12(11-1-2-11)7-16(18)20(26)27/h3-11,25H,1-2H2,(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	38	n/a	n/a	n/a	n/a	8.0	n/a
Almirall, S.A. US Patent					Assay Description Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...				US Patent US8536165 (2013) BindingDB Entry DOI: 10.7270/Q2C24V2G
					More data for this Ligand-Target Pair