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SMILES: COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(CN3CCN(CC3)C(C)C)cc2)c2nccnc12

InChI Key: InChIKey=PZXSXWSNCFKFNX-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 102506   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM102506 (US8536175, 11) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(CN3CCN(CC3)C(C)C)cc2)c2nccnc12 |(11.17,2,;9.63,2,;8.86,.67,;9.63,-.67,;8.86,-2,;9.63,-3.33,;11.17,-3.33,;7.32,-2,;6.54,-3.33,;6.54,-.67,;7.32,.67,;6.54,2,;5.01,-.67,;4.24,.67,;2.7,.67,;1.93,-.67,;.38,-.67,;-.38,.67,;-.38,-2,;-1.93,-2,;-2.7,-.67,;-4.24,-.67,;-5.01,-2,;-6.54,-2,;-7.32,-.67,;-6.54,.67,;-7.32,2,;-8.86,2,;-9.63,.67,;-8.86,-.67,;-9.63,3.33,;-11.17,3.33,;-8.86,4.67,;-4.24,-3.33,;-2.7,-3.33,;2.7,-2,;1.93,-3.33,;2.7,-4.67,;4.24,-4.67,;5.01,-3.33,;4.24,-2,)| Show InChI InChI=1S/C31H33Cl2N5O3/c1-19(2)38-15-13-37(14-16-38)18-20-5-7-21(8-6-20)36-31(39)23-10-9-22(29-30(23)35-12-11-34-29)26-27(32)24(40-3)17-25(41-4)28(26)33/h5-12,17,19H,13-16,18H2,1-4H3,(H,36,39)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	25
Novartis AG US Patent					Assay Description The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ...				US Patent US8815901 (2014) BindingDB Entry DOI: 10.7270/Q2XG9PT8
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM102506 (US8536175, 11) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(CN3CCN(CC3)C(C)C)cc2)c2nccnc12 |(11.17,2,;9.63,2,;8.86,.67,;9.63,-.67,;8.86,-2,;9.63,-3.33,;11.17,-3.33,;7.32,-2,;6.54,-3.33,;6.54,-.67,;7.32,.67,;6.54,2,;5.01,-.67,;4.24,.67,;2.7,.67,;1.93,-.67,;.38,-.67,;-.38,.67,;-.38,-2,;-1.93,-2,;-2.7,-.67,;-4.24,-.67,;-5.01,-2,;-6.54,-2,;-7.32,-.67,;-6.54,.67,;-7.32,2,;-8.86,2,;-9.63,.67,;-8.86,-.67,;-9.63,3.33,;-11.17,3.33,;-8.86,4.67,;-4.24,-3.33,;-2.7,-3.33,;2.7,-2,;1.93,-3.33,;2.7,-4.67,;4.24,-4.67,;5.01,-3.33,;4.24,-2,)| Show InChI InChI=1S/C31H33Cl2N5O3/c1-19(2)38-15-13-37(14-16-38)18-20-5-7-21(8-6-20)36-31(39)23-10-9-22(29-30(23)35-12-11-34-29)26-27(32)24(40-3)17-25(41-4)28(26)33/h5-12,17,19H,13-16,18H2,1-4H3,(H,36,39)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Protein kinase activity measured by the microfluidic caliper method.				US Patent US8536175 (2013) BindingDB Entry DOI: 10.7270/Q27D2SSH
					More data for this Ligand-Target Pair