null

SMILES: COc1cc(OC)c(Cl)c(c1F)-c1ccc(C(=O)Nc2ncc(CN3CCNC(=O)C3)[nH]2)c2nccnc12

InChI Key: InChIKey=HKNCLTAHXPLYKK-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 102544   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM102544 (US8536175, 155) Show SMILES COc1cc(OC)c(Cl)c(c1F)-c1ccc(C(=O)Nc2ncc(CN3CCNC(=O)C3)[nH]2)c2nccnc12 |(8.75,4,;9.52,2.67,;8.75,1.33,;9.52,,;8.75,-1.33,;9.52,-2.67,;11.06,-2.67,;7.21,-1.33,;6.44,-2.67,;6.44,,;7.21,1.33,;6.44,2.67,;4.9,,;4.13,1.33,;2.59,1.33,;1.82,,;.28,,;-.49,1.33,;-.49,-1.33,;-2.03,-1.33,;-2.93,-.09,;-4.4,-.56,;-4.4,-2.1,;-5.73,-2.87,;-7.06,-2.1,;-7.06,-.56,;-8.4,.21,;-9.73,-.56,;-9.73,-2.1,;-11.06,-2.87,;-8.4,-2.87,;-2.93,-2.58,;2.59,-1.33,;1.82,-2.67,;2.59,-4,;4.13,-4,;4.9,-2.67,;4.13,-1.33,)| Show InChI InChI=1S/C25H23ClFN7O4/c1-37-16-9-17(38-2)21(27)19(20(16)26)14-3-4-15(23-22(14)29-5-6-30-23)24(36)33-25-31-10-13(32-25)11-34-8-7-28-18(35)12-34/h3-6,9-10H,7-8,11-12H2,1-2H3,(H,28,35)(H2,31,32,33,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Protein kinase activity measured by the microfluidic caliper method.				US Patent US8536175 (2013) BindingDB Entry DOI: 10.7270/Q27D2SSH
					More data for this Ligand-Target Pair