BDBM103631 US8563553, 56

SMILES: CCC(C)S(=O)(=O)Nc1cc(Cl)cc(c1)-c1[nH]c(nc1-c1ccnc(NC[C@H](C)NC(=O)OC)n1)C(C)(C)C

InChI Key: InChIKey=MRPOACDQGFMWBR-VYRBHSGPSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 103631   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human))	BDBM103631 (US8563553, 56) Show SMILES CCC(C)S(=O)(=O)Nc1cc(Cl)cc(c1)-c1[nH]c(nc1-c1ccnc(NC[C@H](C)NC(=O)OC)n1)C(C)(C)C |r| Show InChI InChI=1S/C26H36ClN7O4S/c1-8-16(3)39(36,37)34-19-12-17(11-18(27)13-19)21-22(33-23(32-21)26(4,5)6)20-9-10-28-24(31-20)29-14-15(2)30-25(35)38-7/h9-13,15-16,34H,8,14H2,1-7H3,(H,30,35)(H,32,33)(H,28,29,31)/t15-,16?/m0/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.5	n/a
Novartis AG; IRM LLC US Patent					Assay Description Raf/Mek amplified luminescence proximity homogeneous assay.				US Patent US8563553 (2013) BindingDB Entry DOI: 10.7270/Q2ZP44R7
					More data for this Ligand-Target Pair