BDBM103698 US8563553, 123

SMILES: CNc1nccc(n1)-c1nc([nH]c1-c1cc(F)cc(NS(C)(=O)=O)c1Cl)C1CC1

InChI Key: InChIKey=OBXWGHIIUPFBTP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 103698   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
B-RAF V600E (Homo sapiens (Human))	BDBM103698 (US8563553, 123) Show SMILES CNc1nccc(n1)-c1nc([nH]c1-c1cc(F)cc(NS(C)(=O)=O)c1Cl)C1CC1 Show InChI InChI=1S/C18H18ClFN6O2S/c1-21-18-22-6-5-12(23-18)16-15(24-17(25-16)9-3-4-9)11-7-10(20)8-13(14(11)19)26-29(2,27)28/h5-9,26H,3-4H2,1-2H3,(H,24,25)(H,21,22,23)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	31	n/a	n/a	n/a	n/a	7.5	n/a
Novartis AG; IRM LLC US Patent					Assay Description Raf/Mek amplified luminescence proximity homogeneous assay.				US Patent US8563553 (2013) BindingDB Entry DOI: 10.7270/Q2ZP44R7
					More data for this Ligand-Target Pair