BDBM103705 US8563553, 130

SMILES: COC(=O)N[C@@H](C)CNc1nccc(n1)-c1nc([nH]c1-c1cccc(NS(=O)(=O)C(C)C)c1F)C(C)(C)C

InChI Key: InChIKey=MDPQVRLDMYVXFL-HNNXBMFYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 103705   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human))	BDBM103705 (US8563553, 130) Show SMILES COC(=O)N[C@@H](C)CNc1nccc(n1)-c1nc([nH]c1-c1cccc(NS(=O)(=O)C(C)C)c1F)C(C)(C)C |r| Show InChI InChI=1S/C25H34FN7O4S/c1-14(2)38(35,36)33-17-10-8-9-16(19(17)26)20-21(32-22(31-20)25(4,5)6)18-11-12-27-23(30-18)28-13-15(3)29-24(34)37-7/h8-12,14-15,33H,13H2,1-7H3,(H,29,34)(H,31,32)(H,27,28,30)/t15-/m0/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.780	n/a	n/a	n/a	n/a	7.5	n/a
Novartis AG; IRM LLC US Patent					Assay Description Raf/Mek amplified luminescence proximity homogeneous assay.				US Patent US8563553 (2013) BindingDB Entry DOI: 10.7270/Q2ZP44R7
					More data for this Ligand-Target Pair