BDBM103708 US8563553, 133

SMILES: CS(=O)(=O)Nc1cccc(-c2[nH]c(nc2-c2ccnc(NCC3(CC3)C#N)n2)C2CC2)c1Cl

InChI Key: InChIKey=ZQLFVFLVTODBAS-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 103708   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human))	BDBM103708 (US8563553, 133) Show SMILES CS(=O)(=O)Nc1cccc(-c2[nH]c(nc2-c2ccnc(NCC3(CC3)C#N)n2)C2CC2)c1Cl Show InChI InChI=1S/C22H22ClN7O2S/c1-33(31,32)30-15-4-2-3-14(17(15)23)18-19(29-20(28-18)13-5-6-13)16-7-10-25-21(27-16)26-12-22(11-24)8-9-22/h2-4,7,10,13,30H,5-6,8-9,12H2,1H3,(H,28,29)(H,25,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	35	n/a	n/a	n/a	n/a	7.5	n/a
Novartis AG; IRM LLC US Patent					Assay Description Raf/Mek amplified luminescence proximity homogeneous assay.				US Patent US8563553 (2013) BindingDB Entry DOI: 10.7270/Q2ZP44R7
					More data for this Ligand-Target Pair