BDBM104080 (Z)-5-(3-Bromo-4-(p-tolylthio)benzylidene)-2-thioxothiazolidin-4-one 14::DNA polymerase inhibitor 14
SMILES: Cc1ccc(Sc2ccc(C=C3SC(S)=NC3=O)cc2Br)cc1
InChI Key: InChIKey=HJDVVIOAZHDVQK-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DNA polymerase lambda (Homo sapiens (Human)) | BDBM104080 ((Z)-5-(3-Bromo-4-(p-tolylthio)benzylidene)-2-thiox...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | <1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Konstanz | Assay Description Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec... | ACS Chem Biol 9: 282-90 (2014) Article DOI: 10.1021/cb4007562 BindingDB Entry DOI: 10.7270/Q20K276T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase beta (Homo sapiens (Human)) | BDBM104080 ((Z)-5-(3-Bromo-4-(p-tolylthio)benzylidene)-2-thiox...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | 7.9 | n/a |
University of Konstanz | Assay Description Pol β reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.9, 20mM KCl, 5% (v/v) glycerol, 1mM DTT, 2mM MnCl2, 250nM puri... | ACS Chem Biol 9: 282-90 (2014) Article DOI: 10.1021/cb4007562 BindingDB Entry DOI: 10.7270/Q20K276T | |||||||||||
More data for this Ligand-Target Pair |