BDBM104142 US8575145, 19

SMILES: CC(C)(CO)COc1cccc2ccc(nc12)-c1nnc2cc(CN)ccn12

InChI Key: InChIKey=HQKQOEMBHUHWCM-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 104142   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM104142 (US8575145, 19) Show SMILES CC(C)(CO)COc1cccc2ccc(nc12)-c1nnc2cc(CN)ccn12 Show InChI InChI=1S/C21H23N5O2/c1-21(2,12-27)13-28-17-5-3-4-15-6-7-16(23-19(15)17)20-25-24-18-10-14(11-22)8-9-26(18)20/h3-10,27H,11-13,22H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	7.4	22
Array BioPharma Inc. US Patent					Assay Description The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...				US Patent US8575145 (2013) BindingDB Entry DOI: 10.7270/Q2M90797
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PIM-3 (Rattus norvegicus (Rat))	BDBM104142 (US8575145, 19) Show SMILES CC(C)(CO)COc1cccc2ccc(nc12)-c1nnc2cc(CN)ccn12 Show InChI InChI=1S/C21H23N5O2/c1-21(2,12-27)13-28-17-5-3-4-15-6-7-16(23-19(15)17)20-25-24-18-10-14(11-22)8-9-26(18)20/h3-10,27H,11-13,22H2,1-2H3	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.4	22
Array BioPharma Inc. US Patent					Assay Description The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...				US Patent US8575145 (2013) BindingDB Entry DOI: 10.7270/Q2M90797
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM104142 (US8575145, 19) Show SMILES CC(C)(CO)COc1cccc2ccc(nc12)-c1nnc2cc(CN)ccn12 Show InChI InChI=1S/C21H23N5O2/c1-21(2,12-27)13-28-17-5-3-4-15-6-7-16(23-19(15)17)20-25-24-18-10-14(11-22)8-9-26(18)20/h3-10,27H,11-13,22H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	7.4	22
Array BioPharma Inc. US Patent					Assay Description The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...				US Patent US8575145 (2013) BindingDB Entry DOI: 10.7270/Q2M90797
					More data for this Ligand-Target Pair