BDBM104489 US8575114, I-1

SMILES: OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cn2nc3ccccn3c2=O)c1

InChI Key: InChIKey=UXGKLQMLYTUINP-LHKMKVQPSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 104489   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM104489 (US8575114, I-1) Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cn2nc3ccccn3c2=O)c1 |r| Show InChI InChI=1S/C19H20ClN3O6/c20-12-5-4-10(18-17(27)16(26)15(25)13(9-24)29-18)7-11(12)8-23-19(28)22-6-2-1-3-14(22)21-23/h1-7,13,15-18,24-27H,8-9H2/t13-,15-,16+,17-,18+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	82.8	n/a	n/a	n/a	n/a	n/a	n/a
Albany Molecular Research, Inc. US Patent					Assay Description The inhibitory activity of the compounds of this invention against the SGLT-1 or SGLT-2 transporters.				US Patent US8575114 (2013) BindingDB Entry DOI: 10.7270/Q23B5XTT
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1) (Homo sapiens (Human))	BDBM104489 (US8575114, I-1) Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cn2nc3ccccn3c2=O)c1 |r| Show InChI InChI=1S/C19H20ClN3O6/c20-12-5-4-10(18-17(27)16(26)15(25)13(9-24)29-18)7-11(12)8-23-19(28)22-6-2-1-3-14(22)21-23/h1-7,13,15-18,24-27H,8-9H2/t13-,15-,16+,17-,18+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>9.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AMRI Curated by ChEMBL					Assay Description Inhibition of human SGLT1 expressed in CHOK1 cells assessed as inhibition of [14C]-AMG uptake after 3 hrs by microbeta scintillation counting analysi...				Bioorg Med Chem 22: 3414-22 (2014) Article DOI: 10.1016/j.bmc.2014.04.036 BindingDB Entry DOI: 10.7270/Q2H70HCT
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM104489 (US8575114, I-1) Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cn2nc3ccccn3c2=O)c1 |r| Show InChI InChI=1S/C19H20ClN3O6/c20-12-5-4-10(18-17(27)16(26)15(25)13(9-24)29-18)7-11(12)8-23-19(28)22-6-2-1-3-14(22)21-23/h1-7,13,15-18,24-27H,8-9H2/t13-,15-,16+,17-,18+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	83	n/a	n/a	n/a	n/a	n/a	n/a
AMRI Curated by ChEMBL					Assay Description Inhibition of human SGLT2 expressed in CHOK1 cells assessed as inhibition of [14C]-AMG uptake after 3 hrs by microbeta scintillation counting analysi...				Bioorg Med Chem 22: 3414-22 (2014) Article DOI: 10.1016/j.bmc.2014.04.036 BindingDB Entry DOI: 10.7270/Q2H70HCT
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1) (Homo sapiens (Human))	BDBM104489 (US8575114, I-1) Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cn2nc3ccccn3c2=O)c1 |r| Show InChI InChI=1S/C19H20ClN3O6/c20-12-5-4-10(18-17(27)16(26)15(25)13(9-24)29-18)7-11(12)8-23-19(28)22-6-2-1-3-14(22)21-23/h1-7,13,15-18,24-27H,8-9H2/t13-,15-,16+,17-,18+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.42E+4	n/a	n/a	n/a	n/a	n/a	n/a
Albany Molecular Research, Inc. US Patent					Assay Description The inhibitory activity of the compounds of this invention against the SGLT-1 or SGLT-2 transporters.				US Patent US8575114 (2013) BindingDB Entry DOI: 10.7270/Q23B5XTT
					More data for this Ligand-Target Pair