BindingDB PrimarySearch

BDBM10458 4-AP::4-Aminopyridine 10::CHEMBL284348::DALFAMPRIDINE::pyridin-4-amine

SMILES: Nc1ccncc1

InChI Key: InChIKey=NUKYPUAOHBNCPY-UHFFFAOYSA-N

Data: 4 KI 6 IC50 1 Kd 1 EC50

PDB links: 1 PDB ID matches this monomer. 9 PDB IDs contain this monomer as substructures. 9 PDB IDs contain inhibitors having a similarity of 90% to this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 10458
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Choline transporter (Mus musculus)	BDBM10458 (4-AP \| 4-Aminopyridine 10 \| CHEMBL284348 \| DALFAMP...) Show SMILES Nc1ccncc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	4.81E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern Ohio Universities Colleges of Medicine and Pharmacy Curated by ChEMBL					Assay Description Inhibition of [3H]choline uptake at choline transporter 1 in mouse brain synaptosome				Bioorg Med Chem Lett 20: 4870-7 (2010) Article DOI: 10.1016/j.bmcl.2010.06.090 BindingDB Entry DOI: 10.7270/Q29C6XMQ
					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM10458 (4-AP \| 4-Aminopyridine 10 \| CHEMBL284348 \| DALFAMP...) Show SMILES Nc1ccncc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents	Article	>2.00E+6	n/a	n/a	n/a	n/a	n/a	n/a	7.5	n/a
TBA Curated by ChEMBL					Assay Description Tested for the Inhibition of the catalytic activity of human plasmin at 25 degree C and pH 7.5.				Bioorg Med Chem Lett 7: 1283-1288 (1997) Article DOI: 10.1016/S0960-894X(97)00210-2 BindingDB Entry DOI: 10.7270/Q29W0FZ9
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Trypsin (Bos taurus (bovine))	BDBM10458 (4-AP \| 4-Aminopyridine 10 \| CHEMBL284348 \| DALFAMP...) Show SMILES Nc1ccncc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents	Article	>2.00E+6	n/a	n/a	n/a	n/a	n/a	n/a	7.5	n/a
TBA Curated by ChEMBL					Assay Description Tested for the Inhibition of the catalytic activity of bovine trypsin at 25 degree C and pH 7.5.				Bioorg Med Chem Lett 7: 1283-1288 (1997) Article DOI: 10.1016/S0960-894X(97)00210-2 BindingDB Entry DOI: 10.7270/Q29W0FZ9
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM10458 (4-AP \| 4-Aminopyridine 10 \| CHEMBL284348 \| DALFAMP...) Show SMILES Nc1ccncc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents	Article	>2.00E+6	n/a	n/a	n/a	n/a	n/a	n/a	7.5	n/a
TBA Curated by ChEMBL					Assay Description Tested for the Inhibition of the catalytic activity of human Thrombin at 25 degree C and pH 7.5.				Bioorg Med Chem Lett 7: 1283-1288 (1997) Article DOI: 10.1016/S0960-894X(97)00210-2 BindingDB Entry DOI: 10.7270/Q29W0FZ9
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-gated potassium channel subfamily A member 1/beta-1 (Homo sapiens (Human))	BDBM10458 (4-AP \| 4-Aminopyridine 10 \| CHEMBL284348 \| DALFAMP...) Show SMILES Nc1ccncc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	8.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Dublin Institute of Technology Curated by ChEMBL					Assay Description Binding affinity towards 5-HT3 receptor in rat was evaluated				J Med Chem 60: 2245-2256 (2017) Article DOI: 10.1021/acs.jmedchem.6b01262 BindingDB Entry DOI: 10.7270/Q29K4DHG
Dublin Institute of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM10458 (4-AP \| 4-Aminopyridine 10 \| CHEMBL284348 \| DALFAMP...) Show SMILES Nc1ccncc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	4.40E+6	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibitory concentration against IKr potassium channel				Bioorg Med Chem Lett 14: 4771-7 (2004) Article DOI: 10.1016/j.bmcl.2004.06.070 BindingDB Entry DOI: 10.7270/Q208661K
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
Pteridine reductase 1 (Leishmania major)	BDBM10458 (4-AP \| 4-Aminopyridine 10 \| CHEMBL284348 \| DALFAMP...) Show SMILES Nc1ccncc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	1.90E+6	n/a	n/a	n/a	n/a	n/a	n/a
Rutgers University Curated by ChEMBL					Assay Description Inhibition of Leishmania major PTR1				J Agric Food Chem 59: 56-61 (2011) Article DOI: 10.1021/jm1010572 BindingDB Entry DOI: 10.7270/Q27W6D6P
Rutgers University Curated by ChEMBL					More data for this Ligand-Target Pair
Twik-RElated Potassium (K+) channel 1 (TREK1) (Homo sapiens (Human))	BDBM10458 (4-AP \| 4-Aminopyridine 10 \| CHEMBL284348 \| DALFAMP...) Show SMILES Nc1ccncc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	2.75E+6	n/a	n/a	7.3	22
Korea Institute of Science and Technology					Assay Description The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...				Chem Biol Drug Des 88: 807-819 (2016) Article DOI: 10.1111/cbdd.12810 BindingDB Entry DOI: 10.7270/Q2S181B1
Korea Institute of Science and Technology					More data for this Ligand-Target Pair
Carboxylic ester hydrolase (Rattus norvegicus (rat))	BDBM10458 (4-AP \| 4-Aminopyridine 10 \| CHEMBL284348 \| DALFAMP...) Show SMILES Nc1ccncc1 Show InChI	Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Hong Kong University of Science and Technology					Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...				Bioorg Med Chem 7: 2569-75 (1999) Article DOI: 10.1016/s0968-0896(99)00178-9 BindingDB Entry DOI: 10.7270/Q22N50GZ
Hong Kong University of Science and Technology					More data for this Ligand-Target Pair
Acetylcholinesterase (Rattus norvegicus (rat))	BDBM10458 (4-AP \| 4-Aminopyridine 10 \| CHEMBL284348 \| DALFAMP...) Show SMILES Nc1ccncc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	7.4	37
Hong Kong University of Science and Technology					Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...				Bioorg Med Chem 7: 2569-75 (1999) Article DOI: 10.1016/s0968-0896(99)00178-9 BindingDB Entry DOI: 10.7270/Q22N50GZ
Hong Kong University of Science and Technology					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM10458 (4-AP \| 4-Aminopyridine 10 \| CHEMBL284348 \| DALFAMP...) Show SMILES Nc1ccncc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	4.37E+6	n/a	n/a	n/a	n/a	n/a	n/a
TCG Lifesciences Ltd. Curated by ChEMBL					Assay Description Inhibition of human ERG				Eur J Med Chem 46: 618-30 (2011) Article DOI: 10.1016/j.ejmech.2010.11.042 BindingDB Entry DOI: 10.7270/Q2WQ052W
TCG Lifesciences Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-gated potassium channel (Homo sapiens (Human))	BDBM10458 (4-AP \| 4-Aminopyridine 10 \| CHEMBL284348 \| DALFAMP...) Show SMILES Nc1ccncc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	n/a	1.95E+5	n/a	n/a	n/a	n/a	n/a
Institute of Medical Research Biotechnology Centre Curated by ChEMBL					Assay Description Dissociation constant for the blockage of voltage-gated potassium channel subunit Kv1.3 in human lymphocytes				J Med Chem 47: 2326-36 (2004) Article DOI: 10.1021/jm030523s BindingDB Entry DOI: 10.7270/Q28W3CRM
					More data for this Ligand-Target Pair