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SMILES: COc1ncc(cn1)-c1c(nc(N2CCC(CC2)N(C)C)c2cncn12)-c1ccc(cc1)C#N

InChI Key: InChIKey=XXRVQYNQKVZTQU-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 106024   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM106024 (US10047086, 150 | US10640503, Example 150 | US9695...) Show SMILES COc1ncc(cn1)-c1c(nc(N2CCC(CC2)N(C)C)c2cncn12)-c1ccc(cc1)C#N Show InChI InChI=1S/C25H26N8O/c1-31(2)20-8-10-32(11-9-20)24-21-15-27-16-33(21)23(19-13-28-25(34-3)29-14-19)22(30-24)18-6-4-17(12-26)5-7-18/h4-7,13-16,20H,8-11H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM106024 (US10047086, 150 | US10640503, Example 150 | US9695...) Show SMILES COc1ncc(cn1)-c1c(nc(N2CCC(CC2)N(C)C)c2cncn12)-c1ccc(cc1)C#N Show InChI InChI=1S/C25H26N8O/c1-31(2)20-8-10-32(11-9-20)24-21-15-27-16-33(21)23(19-13-28-25(34-3)29-14-19)22(30-24)18-6-4-17(12-26)5-7-18/h4-7,13-16,20H,8-11H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...				US Patent US10640503 (2020)
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM106024 (US10047086, 150 | US10640503, Example 150 | US9695...) Show SMILES COc1ncc(cn1)-c1c(nc(N2CCC(CC2)N(C)C)c2cncn12)-c1ccc(cc1)C#N Show InChI InChI=1S/C25H26N8O/c1-31(2)20-8-10-32(11-9-20)24-21-15-27-16-33(21)23(19-13-28-25(34-3)29-14-19)22(30-24)18-6-4-17(12-26)5-7-18/h4-7,13-16,20H,8-11H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	7.5	n/a
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...				US Patent US10047086 (2018) BindingDB Entry DOI: 10.7270/Q28917W4
					More data for this Ligand-Target Pair