null

SMILES: CN1CCC[C@@H](COc2cc(-c3ccc(cc3)C#N)c(-c3ccc(nc3)C(C)(C)O)n3cncc23)C1

InChI Key: InChIKey=BDEBMWNWXASQOT-OAQYLSRUSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 106044   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific histone demethylase 1A [151-852] (Homo sapiens (Human))	BDBM106044 (US10047086, 151 | US10640503, Example 151 | US9695...) Show SMILES CN1CCC[C@@H](COc2cc(-c3ccc(cc3)C#N)c(-c3ccc(nc3)C(C)(C)O)n3cncc23)C1 |r| Show InChI InChI=1S/C29H31N5O2/c1-29(2,35)27-11-10-23(15-32-27)28-24(22-8-6-20(14-30)7-9-22)13-26(25-16-31-19-34(25)28)36-18-21-5-4-12-33(3)17-21/h6-11,13,15-16,19,21,35H,4-5,12,17-18H2,1-3H3/t21-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	7.5	25
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay¿10 uL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM Na...				US Patent US9695168 (2017) BindingDB Entry DOI: 10.7270/Q2SX6BCD
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM106044 (US10047086, 151 | US10640503, Example 151 | US9695...) Show SMILES CN1CCC[C@@H](COc2cc(-c3ccc(cc3)C#N)c(-c3ccc(nc3)C(C)(C)O)n3cncc23)C1 |r| Show InChI InChI=1S/C29H31N5O2/c1-29(2,35)27-11-10-23(15-32-27)28-24(22-8-6-20(14-30)7-9-22)13-26(25-16-31-19-34(25)28)36-18-21-5-4-12-33(3)17-21/h6-11,13,15-16,19,21,35H,4-5,12,17-18H2,1-3H3/t21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...				US Patent US10640503 (2020)
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM106044 (US10047086, 151 | US10640503, Example 151 | US9695...) Show SMILES CN1CCC[C@@H](COc2cc(-c3ccc(cc3)C#N)c(-c3ccc(nc3)C(C)(C)O)n3cncc23)C1 |r| Show InChI InChI=1S/C29H31N5O2/c1-29(2,35)27-11-10-23(15-32-27)28-24(22-8-6-20(14-30)7-9-22)13-26(25-16-31-19-34(25)28)36-18-21-5-4-12-33(3)17-21/h6-11,13,15-16,19,21,35H,4-5,12,17-18H2,1-3H3/t21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	7.5	n/a
Incyte Corporation US Patent					Assay Description LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...				US Patent US10047086 (2018) BindingDB Entry DOI: 10.7270/Q28917W4
					More data for this Ligand-Target Pair