BDBM106564 US8586600, II-23

SMILES: Cc1ccc(NC(=O)c2ccc(NS(=O)(=O)C=C)cc2)cc1Nc1nccc(n1)-c1cccnc1

InChI Key: InChIKey=BQQNUYWCLMCSAG-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 106564   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM106564 (US8586600, II-23) Show SMILES Cc1ccc(NC(=O)c2ccc(NS(=O)(=O)C=C)cc2)cc1Nc1nccc(n1)-c1cccnc1 Show InChI InChI=1S/C25H22N6O3S/c1-3-35(33,34)31-20-10-7-18(8-11-20)24(32)28-21-9-6-17(2)23(15-21)30-25-27-14-12-22(29-25)19-5-4-13-26-16-19/h3-16,31H,1H2,2H3,(H,28,32)(H,27,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Avilomics Research, Inc. US Patent					Assay Description Compounds may be screened for their ability to inhibit KDR using a standard coupled enzyme assay (Fox et al., Protein Sci., (1998) 7, 2249).				US Patent US8586600 (2013) BindingDB Entry DOI: 10.7270/Q2M61HWH
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM106564 (US8586600, II-23) Show SMILES Cc1ccc(NC(=O)c2ccc(NS(=O)(=O)C=C)cc2)cc1Nc1nccc(n1)-c1cccnc1 Show InChI InChI=1S/C25H22N6O3S/c1-3-35(33,34)31-20-10-7-18(8-11-20)24(32)28-21-9-6-17(2)23(15-21)30-25-27-14-12-22(29-25)19-5-4-13-26-16-19/h3-16,31H,1H2,2H3,(H,28,32)(H,27,29,30)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18.8	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Avilomics Research, Inc. US Patent					Assay Description Compounds may also be assayed as inhibitors of PDGFR in a manner substantially similar to the method described in Roberts, et al., “Antiangiogen...				US Patent US8586600 (2013) BindingDB Entry DOI: 10.7270/Q2M61HWH
					More data for this Ligand-Target Pair